Table 3.
Electric charge dependence of virus mutation1.
| Macro-lineages | Mutant | Number of AA sites | Positively charged | Negatively charged | Neutrally charged |
|---|---|---|---|---|---|
| N-lineage | Lambda | 14 | 3 | 1 | 10 |
| Gamma | 12 | 3 | 5 | 6 | |
| Beta | 10 | 5 | 2 | 4 | |
| Alpha | 10 | 5 | 3 | 3 | |
| Mu | 9 | 7 | 1 | 2 | |
| Eta | 9 | 6 | 1 | 3 | |
| Delta | 9 | 7 | 1 | 1 | |
| Theta | 7 | 6 | 3 | 1 | |
| Kappa | 5 | 5 | 0 | 0 | |
| Iota | 4 | 2 | 0 | 2 | |
| Epsilon | 4 | 2 | 0 | 2 | |
| Zeta | 3 | 3 | 0 | 1 | |
| O-lineage | BA.1 | 33 | 16 | 6 | 13 |
| BA.5 | 34 | 14 | 8 | 14 |
1
The basic residue is assigned a charge of +1, the acidic residue a charge of −1, and all others are assigned a charge of 0. The increase in charge is determined by the algebraic difference between the mutated residue and the wild type. The positive (negative) values in the table represent the sum of charge increases for residues with positive (negative) charge. The neutral values in the table correspond to the total number of residues with no change in charge.