Skip to main content
. 2024 Feb 23;10(3):666–675. doi: 10.1021/acscentsci.3c01310

Figure 3.

Figure 3

PolySTING inhibits tumor growth and prolongs survival in tumor-bearing mice. (a) Tumor growth curve in B16-F10 tumor-bearing C57BL/6 mice. B16-F10 cells were inoculated on day −8, and STING treatments were given on days 0, 4, and 8 through intravenous injections. Data are represented as mean ± SEM (N = 8–10). Statistical analysis was performed using mixed effects of the analysis of two-way ANOVA with Tukey’s multiple comparisons test (**p ≤ 0.01, between free STING and polySTING). (b) Kaplan–Meier survival curve (N = 8–10). Survival analysis was performed using the log-rank test (***p ≤ 0.001). (c) Weight change in B16-F10 tumor-bearing C57BL/6 mice. Data are represented as the mean ± SD (N = 8–10). (d) Plasma IFNβ level in 4T1 tumor-bearing BALB/c mice 4 h post-treatment with free STING and polySTING (N = 5). Data are represented as the mean ± SD. Statistical analysis was performed using one-way ANOVA with a posthoc Tukey HSD test (****p ≤ 0.0001).