eTable 1. Recommendations for the administration of therapeutic plasma to premature infants and neonates, infants, and children, modified according to the cross-sectional guideline (10).

Recommendations	Level of evidence
Plasma combined with red blood cell concentrates could be used as priming fluid in neonates and infants undergoing cardiopulmonary bypass surgery or extracorporeal membrane oxygenation.	2C
Exchange transfusion in neonates shall be performed using red blood cell concentrates and plasma.	1C+
Plasma shall not be transfused prophylactically in premature infants with the objective of preventing intracerebral bleeding.	1A
Plasma shall not be transfused in children with hemolytic uremic syndrome without coagulopathy.	1B
Partial exchange transfusion in neonates with polycythemia and hyperviscosity syndrome shall not be performed using plasma.	1B

Level of evidence:

1A: strong recommendation valid for most patients

1B: strong recommendation probably valid for most patients

1C+: strong recommendation valid for most patients.

Depending on the individual case, a different course of action may be indicated. The most important recommendation is not to transfuse therapeutic plasma prophylactically in preterm infants with the objective of preventing intracerebral hemorrhage.

2C: very weak recommendation. Depending on the individual case, a different course of action may be indicated.