Figure 3. Continuous spectrum of vascular severity in ROP from normal to plus disease.

All 34 members of this committee graded 30 images as normal, pre-plus, or plus. Experts’ opinions varied as to the level of disease severity that constitutes pre-plus and plus disease. (A) Six representative images are displayed, where color scale on top reflects the average grading of committee members (from green = normal to red = plus), and demonstrates that vascular severity presents on a continuum. (B) Nine representative segmented images are displayed, where color scale represents mean vascular severity grading by committee members for each image (from green = normal to red = plus), and demonstrates that vascular severity presents on a continuum.