TABLE 2.
Baseline patient and disease characteristics (categorical variables).
| PFS | OS | |||||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| Categorical variable | N | % | HR | 95% CI | p | HR | 95% CI | p |
| LDH elevated | ||||||||
| Yes | 157 | 29 | 1.202 | 0.948–1.523 | 0.13 | 1.148 | 0.875–1.507 | 0.026 |
| No | 287 | 53 | ||||||
| NA | 95 | 18 | ||||||
| Prior or concurrent malignancy | ||||||||
| Yes | 122 | 23 | 1.074 | 0.839–1.375 | 0.572 | 1.148 | 0.875–1.507 | .3188 |
| No | 414 | 77 | ||||||
| NA | 3 | .006 | ||||||
| Prior organ transplant | ||||||||
| Yes | 43 | 8 | 0.933 | 0.626–1.391 | 0.732 | 1.149 | 0.756–1.745 | .516 |
| No | 494 | 92 | ||||||
| NA | 2 | .03 | ||||||
| CSF protein elevated | ||||||||
| Yes | 233 | 43 | 1.157 | 0.872–1.536 | .311 | 0.953 | 0.697–1.303 | 0.764 |
| No | 111 | 20 | ||||||
| NA | 195 | 36 | ||||||
| CSF involved | ||||||||
| Yes | 68 | 13 | 0.881 | 0.637–1.219 | .444 | 1.043 | 0.736–1.477 | .815 |
| No | 325 | 60 | ||||||
| NA | 146 | 27 | ||||||
| Ocular involvement | ||||||||
| Yes | 52 | 10 | 0.938 | 0.659–1.337 | .724 | 0.780 | 0.515–1.182 | .242 |
| No | 385 | 71 | ||||||
| NA | 102 | 19 | ||||||
| Cell of origin | ||||||||
| GC | 70 | 13 | ||||||
| Non-GC | 219 | 40 | 0.858 | 0.620–1.187 | .355 | 0.880 | 0.610–1.270 | .495 |
| NA | 250 | 46 | ||||||
| Double expressor (cmyc and bcl2) by IHC | ||||||||
| Yes | 74 | 14 | 0.8 | 0.542–1.181 | .2618 | 0.890 | 0.573–1.382 | .604 |
| No | 108 | 20 | ||||||
| NA | 357 | 66 | ||||||
| MYC translocation by FISH | ||||||||
| Yes | 27 | 5 | 1.791 | 1.11–2,89 | .0169 | 1.634 | 0.917–2.909 | .0954 |
| No | 128 | 24 | ||||||
| NA | 384 | 71 | ||||||
| EBER | ||||||||
| Positive | 33 | 6 | .764 | .476–1.228 | .2666 | .890 | .538–1473 | .6501 |
| Negative | 279 | 52 | ||||||
| NA | 227 | 42 | ||||||
| Number of parenchymal sites | ||||||||
| 1 | 239 | 44 | 1.014 | .820–1.255 | .8983 | .935 | .736–1.188 | .5816 |
| >1 | 271 | 50 | ||||||
| NA | 29 | 5 | ||||||
| Geriatric syndrome | ||||||||
| Yes | 247 | 46 | 1.402 | 1.137–1.729 | .0016 | 1.625 | 1.283–2.058 | <.0001 |
| No | 282 | 52 | ||||||
| NA | 10 | 2 | ||||||
| Impairment in any ADL | ||||||||
| Yes | 193 | 36 | 1.403 | 1.127–1.745 | .0024 | 1.712 | 1.341–2.187 | <.0001 |
| No | 314 | 58 | ||||||
| NA | 32 | 6 | ||||||
| ECOG PS | ||||||||
| 0 | 60 | 11 | ||||||
| 1 | 162 | 31 | 1.062 | .728–1.548 | .7555 | 1.453 | .896–2.357 | .130 |
| 2 | 154 | 29 | 1.378 | .947–2.005 | .0942 | 2.051 | 1.274–3.300 | .0031 |
| 3 | 66 | 12 | 1.576 | 1.026–2.422 | .0377 | 2.817 | 1.677–4.733 | <.0001 |
| 4 | 25 | 5 | 3.238 | 1.873–5.596 | <.0001 | 5.655 | 3.052–10.48 | <.0001 |
| NA | 72 | 13 | ||||||