Table 2.
Modelled effect sizes from restricted cubic splines (RCS) analyses, depicting adjusted association between BMI and perioperative outcomes of laparoscopic liver resection. Reference BMI is set as 25kg/m2 and treatment effects were adjusted using covariance adjustment for baseline covariates
| BMI (kg/m2) | Operation time (mins) MD (95% CI) | Estimated blood loss (ml) MD (95% CI) | Pringle maneuver RR (95% CI) | Blood transfusion RR (95% CI) | Open conversion RR (95% CI) | Post-op complications RR (95% CI) | Major complications RR (95% CI) | Post-op length of stay MD (95% CI) | 90-day mortality RR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| 15 | −24 (−46 to −1) | 3 (−65 to 71) | 1.19 (0.79 to 1.79) | 1.2 (0.54 to 2.68) | 0.7 (0.25 to 1.95) | 1.19 (0.59 to 2.4) | 1.66 (0.61 to 4.46) | 0.2 (−0.4 to 0.8) | 2.46 (0.31 to 19.42) |
| 16 | −22 (−42 to −3) | 0 (−57 to 58) | 1.14 (0.8 to 1.61) | 1.17 (0.58 to 2.39) | 0.73 (0.29 to 1.8) | 1.16 (0.64 to 2.1) | 1.57 (0.65 to 3.77) | 0.2 (−0.3 to 0.7) | 2.23 (0.36 to 13.99) |
| 17 | −21 (−37 to −4) | −3 (−50 to 45) | 1.09 (0.82 to 1.45) | 1.14 (0.61 to 2.13) | 0.75 (0.34 to 1.66) | 1.12 (0.69 to 1.84) | 1.48 (0.69 to 3.18) | 0.2 (−0.2 to 0.7) | 2.02 (0.41 to 10.08) |
| 18 | −19 (−32 to −6) | −5 (−44 to 33) | 1.04 (0.83 to 1.31) | 1.12 (0.65 to 1.9) | 0.78 (0.39 to 1.53) | 1.09 (0.74 to 1.62) | 1.4 (0.73 to 2.69) | 0.2 (−0.1 to 0.6) | 1.83 (0.46 to 7.26) |
| 19 | −18 (−28 to −8) | −8 (−38 to 21) | 1 (0.84 to 1.18) | 1.09 (0.7 to 1.69) | 0.81 (0.46 to 1.42) | 1.06 (0.79 to 1.43) | 1.32 (0.77 to 2.27) | 0.2 (0 to 0.5) | 1.66 (0.53 to 5.24) |
| 20 | −16 (−24 to −9) | −11 (−33 to 11) | 0.95 (0.84 to 1.08) | 1.06 (0.74 to 1.51) | 0.83 (0.53 to 1.31) | 1.03 (0.82 to 1.29) | 1.25 (0.82 to 1.92) | 0.2 (0 to 0.4) | 1.51 (0.6 to 3.78) |
| 21 | −14 (−20 to −9) | −13 (−31 to 5) | 0.92 (0.83 to 1.02) | 1.03 (0.79 to 1.35) | 0.86 (0.62 to 1.21) | 1 (0.84 to 1.19) | 1.19 (0.86 to 1.63) | 0.2 (0.1 to 0.4) | 1.37 (0.69 to 2.74) |
| 22 | −12 (−17 to −7) | −13 (−29 to 3) | 0.91 (0.83 to 0.99) | 1.01 (0.84 to 1.21) | 0.89 (0.71 to 1.13) | 0.99 (0.85 to 1.15) | 1.12 (0.91 to 1.39) | 0.2 (0.1 to 0.3) | 1.25 (0.77 to 2.01) |
| 23 | −9 (−13 to −5) | −11 (−24 to 2) | 0.91 (0.85 to 0.98) | 1 (0.9 to 1.11) | 0.93 (0.81 to 1.06) | 0.98 (0.86 to 1.11) | 1.07 (0.95 to 1.22) | 0.2 (0 to 0.3) | 1.14 (0.86 to 1.53) |
| 24 | −5 (−7 to −2) | −7 (−14 to 1) | 0.95 (0.91 to 0.99) | 0.99 (0.95 to 1.04) | 0.96 (0.91 to 1.02) | 0.98 (0.91 to 1.06) | 1.03 (0.97 to 1.09) | 0.1 (0 to 0.1) | 1.06 (0.93 to 1.21) |
| 25 | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
| 26 | 4 (2 to 7) | 7 (0 to 15) | 1.06 (1.02 to 1.1) | 1.02 (0.98 to 1.06) | 1.04 (1 to 1.08) | 1.03 (0.95 to 1.1) | 0.98 (0.93 to 1.04) | −0.1 (−0.1 to 0) | 0.96 (0.86 to 1.07) |
| 27 | 8 (4 to 12) | 14 (2 to 27) | 1.11 (1.03 to 1.19) | 1.05 (0.98 to 1.13) | 1.09 (1.01 to 1.16) | 1.06 (0.93 to 1.2) | 0.97 (0.86 to 1.09) | −0.2 (−0.3 to 0) | 0.92 (0.74 to 1.15) |
| 28 | 11 (6 to 16) | 21 (5 to 36) | 1.15 (1.06 to 1.26) | 1.09 (0.99 to 1.21) | 1.13 (1.03 to 1.25) | 1.1 (0.94 to 1.28) | 0.96 (0.79 to 1.18) | −0.2 (−0.3 to −0.1) | 0.9 (0.64 to 1.27) |
| 29 | 13 (8 to 19) | 27 (9 to 44) | 1.19 (1.08 to 1.32) | 1.15 (0.99 to 1.32) | 1.18 (1.04 to 1.34) | 1.14 (0.96 to 1.36) | 0.96 (0.72 to 1.29) | −0.3 (−0.4 to −0.1) | 0.89 (0.55 to 1.42) |
| 30 | 15 (9 to 22) | 32 (14 to 51) | 1.22 (1.09 to 1.36) | 1.2 (1 to 1.45) | 1.24 (1.05 to 1.46) | 1.19 (0.99 to 1.43) | 0.97 (0.65 to 1.43) | −0.3 (−0.5 to −0.1) | 0.88 (0.47 to 1.63) |
| 31 | 17 (10 to 24) | 38 (17 to 59) | 1.24 (1.11 to 1.39) | 1.27 (1 to 1.61) | 1.29 (1.05 to 1.59) | 1.25 (1.03 to 1.51) | 0.97 (0.59 to 1.6) | −0.3 (−0.5 to −0.2) | 0.87 (0.4 to 1.88) |
| 32 | 18 (10 to 26) | 43 (19 to 68) | 1.26 (1.11 to 1.42) | 1.33 (1 to 1.78) | 1.35 (1.04 to 1.75) | 1.31 (1.07 to 1.61) | 0.98 (0.53 to 1.79) | −0.4 (−0.6 to −0.2) | 0.86 (0.34 to 2.18) |
| 33 | 19 (10 to 28) | 49 (20 to 77) | 1.27 (1.11 to 1.47) | 1.41 (1 to 1.97) | 1.41 (1.04 to 1.91) | 1.38 (1.1 to 1.72) | 0.98 (0.48 to 2.01) | −0.4 (−0.6 to −0.2) | 0.85 (0.29 to 2.53) |
| 34 | 20 (10 to 31) | 54 (20 to 88) | 1.29 (1.1 to 1.51) | 1.48 (1 to 2.19) | 1.47 (1.03 to 2.1) | 1.44 (1.13 to 1.85) | 0.99 (0.43 to 2.25) | −0.4 (−0.7 to −0.2) | 0.84 (0.24 to 2.94) |
| 35 | 22 (9 to 34) | 59 (20 to 99) | 1.31 (1.09 to 1.57) | 1.56 (1 to 2.43) | 1.54 (1.03 to 2.31) | 1.52 (1.15 to 2) | 0.99 (0.39 to 2.52) | −0.5 (−0.8 to −0.1) | 0.83 (0.2 to 3.42) |
| 36 | 23 (9 to 37) | 65 (20 to 110) | 1.32 (1.08 to 1.63) | 1.64 (1 to 2.69) | 1.61 (1.02 to 2.53) | 1.59 (1.16 to 2.17) | 1 (0.35 to 2.82) | −0.5 (−0.8 to −0.1) | 0.83 (0.17 to 3.98) |
| 37 | 24 (8 to 39) | 70 (19 to 121) | 1.34 (1.06 to 1.69) | 1.73 (1 to 2.98) | 1.68 (1.02 to 2.78) | 1.67 (1.18 to 2.37) | 1 (0.32 to 3.16) | −0.5 (−0.9 to −0.1) | 0.82 (0.14 to 4.63) |
| 38 | 25 (7 to 42) | 75 (18 to 133) | 1.36 (1.05 to 1.76) | 1.82 (1 to 3.31) | 1.76 (1.01 to 3.06) | 1.75 (1.19 to 2.59) | 1.01 (0.29 to 3.55) | −0.5 (−1 to −0.1) | 0.81 (0.12 to 5.39) |
| 39 | 26 (7 to 45) | 81 (17 to 144) | 1.37 (1.03 to 1.83) | 1.92 (1 to 3.67) | 1.84 (1.01 to 3.36) | 1.84 (1.2 to 2.83) | 1.02 (0.26 to 3.98) | −0.6 (−1.1 to −0.1) | 0.8 (0.1 to 6.27) |
| 40 | 27 (6 to 49) | 86 (16 to 156) | 1.39 (1.02 to 1.9) | 2.02 (1 to 4.08) | 1.92 (1 to 3.69) | 1.93 (1.21 to 3.09) | 1.02 (0.23 to 4.46) | −0.6 (−1.2 to 0) | 0.8 (0.09 to 7.3) |