Table 2:
Pharmacokinetics parameters of THC in female Sprague Dawley rats. Abbreviations: Cmax, maximum serum concentration; AUCinf, area under the curve from 5 minutes post-exposure to infinity; ke, elimination rate constant; t1/2, terminal half-life; Vd/F, volume of distribution; Vss, volume of distribution at steady state; CL or CL/F, clearance; **, indicating apparent volume of distribution or clearance.
| Parameter | 2 mg/kg i.p. | 0.19 mg/kg vaporized | 0.76 mg/kg vaporized |
|---|---|---|---|
| Cmax (ng/mL) | 107.7 | 43.3 | 71.6 |
| Tmax (min) | 10 | 10 | 5 |
| AUCinf (hr*ng/mL) | 364.4 | 87.0 | 94.4 |
| ke (1/hr) | 0.2 | 0.3 | 0.3 |
| t1/2 (hr) | 3.4 | 2.2 | 2.7 |
| Vd/F** (L/kg) | 26.9 | 7.4 | 33.0 |
| Vss (L/kg) | - | 8.6 | 24.4 |
| CL or CL/F** (L/hr/kg) | 5.5** | 2.3 | 8.5 |