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[Preprint]. 2024 Mar 11:2024.03.11.583978. [Version 1] doi: 10.1101/2024.03.11.583978

FIG 1. Infectivity of BA.2.87.1 and JN.1 in 293T-ACE2 and CaLu-3 cells.

FIG 1

(a) A schematic depiction comparing spike mutations in the studied variants including BA.2.87.1 and JN.1 by amino acid numbers. NTD = N-terminal domain, RBD = receptor binding domain; S2: the S2 subunit region. (b-c) Relative infectivity of lentiviral pseudotypes bearing each of the listed spikes in (b) 293T cells expressing human ACE2 (293T-ACE2) and (c) human lung cell line CaLu-3. Relative luminescence readouts were normalized to D614G (D614G = 1.0). Bars in (b–c) represent means ± standard error from triplicates of transfection. Significance relative to D614G was analyzed by a one-way repeated measures ANOVA with Bonferroni’s multiple testing correction (n = 6). p values are displayed as ns p > 0.05, ***p < 0.001, and ****p < 0.0001.