Figure 4. CD49a⁺ CD4⁺ TRM gene signature indicates the ability to bind and alter the extracellular matrix.

CD49a⁻ and CD49a⁺ CD4⁺ T cells were sorted from lungs of mice which had received intranasal FluMist^® 28 days prior. RNA was isolated and subjected to RNA seq analysis. A. STRING clustering figure of the 500 most differentially expressed genes by CD49a⁺ CD4⁺ TRM. B. Differential gene expression analysis of CD49a⁺ CD4⁺ TRM versus CD49a⁻ CD4⁺ TRM.