Extended Data Fig. 4.

related to Fig. 3. Volcano plots depicting negative log₁₀ FDR-adjusted p-values and log₂ fold changes between case and control in a) proteomics from Aβ_1–42 transgenic flies (amyloid β), b) proteomics from tau^R406W transgenic flies, c) phosphoproteomics from Aβ_1–42 transgenic flies, d) phosphoproteomics from tau^R406W transgenic flies, e) metabolomics from Aβ_1–42 transgenic flies, and f) metabolomics from tau^R406W transgenic flies Blue dots indicate significantly downregulated omics and red dots indicate significantly upregulated omics. The horizontal red dashed line indicates the FDR cut-off at 0.1. g) Dot plot indicating GO terms overrepresented in neurodegeneration screen hits that are differentially abundant in proteomics from Aβ_1–42 transgenic flies.