Table 1. Hits from the age-associated neurodegeneration screen:
List of Drosophila genes and human orthologs that were hits from the screen for age-associated neurodegeneration. Human orthologs of genetic screen hits in Drosophila were inferred using DIOPT126.
| Drosophila gene | human gene | function |
|---|---|---|
| Adf1 | ||
| Adh | HPGD | |
| AlCR2 | SSTR2 | Somatostatin receptor type 2 |
| alien | COPS2 | COP9 signalosome complex subunit 2 |
| AP-1gamma | AP1G1 | AP-1 complex subunit gamma-1 |
| AP-50 | AP2M1 | Clathrin coat assembly protein AP50 |
| Apc | APC | Adenomatous polyposis coli protein |
| Aph-4 | ALPP | Alkaline phosphatase |
| aPKC | PRKCI | Atypical protein kinase C-lambda/iota |
| Appl | APP | Amyloid precursor protein |
| arm | CTNNB1 | Beta-catenin |
| Arp8 | ACTR8 | actin binding |
| Arpc3A | ARPC3 | actin binding |
| Atg18 | WIPI2 | WD repeat domain phosphoinositide-interacting protein 2 |
| Atg8a | GABARAP | LC3, autophagy |
| Atx-1 | ATXN1 | |
| barr | NCAPH | non-SMC condensin I complex |
| bel | DDX3X | ATP-dependent RNA helicase DDX3X |
| BicD | BICD1 | bicaudal D homolog 1 |
| bif | actin binding | |
| burs | neuropeptide, not conserved | |
| Cad99C | PCDH15 | Protocadherin-15 |
| CAP-D2 | NCAPD2 | Condensin complex subunit 1 |
| cdi | TESK2 | |
| cdm | IPO13 | Karyopherin-13 |
| CG10200 | ||
| CG10738 | NPR1 | |
| CG10864 | KCNK18 | K channel |
| CG11105 | NKD1 | naked cuticle homolog 1 |
| CG11198 | ACACA | acetyl-Coenzyme A carboxylase |
| CG11723 | ||
| CG12455 | CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit |
| CG13253 | ||
| CG13779 | SHFM1 | protease |
| CG1440 | BLMH | bleomycin hydrolase |
| CG14419 | ||
| CG15021 | ||
| CG15177 | EFCAB1 | |
| CG15658 | ||
| CG1908 | ||
| CG2116 | transcription factor, not conserved | |
| CG30020 | transcription factor | |
| CG30203 | SPON1 | protease inhibitor |
| CG31105 | sodium trnasporter | |
| CG33213 | transcription factor | |
| CG33231 | SVIL | gelsolin-like, actin binding |
| CG33673 | ||
| CG33967 | KIBRA | WW domain-containing protein 1 |
| CG34402 | ||
| CG34422 | ARID4A | Retinoblastoma-binding protein 1 |
| CG42260 | CNGA2 | cyclic nucleotide activated channel |
| CG42534 | ||
| CG42573 | ||
| CG4596 | TMEM169 | |
| CG6044 | ||
| CG6498 | MAST1 | Microtubule-associated serine/threonine-protein kinase 1 |
| CG7023 | USP12 | |
| CG7526 | LTBP1 | TGF-beta1-BP-1 |
| CG7841 | C16orf14 | |
| CG8245 | TMEM53 | Transmembrane protein 53 |
| CG9086 | UBR2 | E3 ubiquitin-protein ligase UBR2 |
| CG9934 | UBE4B | Ubiquitin conjugation factor E4 B |
| Cha | CHAT | |
| CheB38a | ||
| Chmp1 | Chmp1b | Chmp1b |
| chn | transcription factor, not conserved | |
| CkIalpha | CSNK1A1 | |
| CkIIalpha | CSNK2A1 | |
| CkIIbeta | CSNK2B | |
| Clc | CLTB | Clathrin light chain B |
| Cont | CNTN6 | contactin 6 |
| CoRest | RCOR2 | REST corepressor 2 |
| CG5037 | COX10 | cytochrome-c oxidase |
| crb | CRB1 | Crumbs homolog 1 |
| crm | CRAMP1L | chromatin regulation |
| csw | PTPN11 | protein tyrosine phosphatase |
| ct | CUX1 | Protein CASP/transcription factor |
| cwo | BHLHE41 | Class E basic helix-loop-helix protein 41 |
| dco | CSNK1E | Casein kinase I-epsilon |
| Dl | DLL1 | Delta-like protein 1 |
| dm | MYC | Myc |
| dock | NCK1 | NCK adaptor protein 1 |
| ear | MLLT1 | Protein ENL |
| Eb1 | MAPRE1 | Microtubule-associated protein RP/EB family member 1 |
| Egfr | ERBB3 | |
| Eip75B | NR1D1 | nuclear receptor |
| endoB | SH3GLB2 | Endophilin-B2 |
| epsilonCOP | COPE | |
| exo84 | EXOC8 | exocyst complex component 8 |
| ey | PAX6 | |
| eya | EYA1 | Eyes absent homolog 1 |
| fliI | FLII | flightless-1 homolog |
| fng | RFNG | Beta-1,3-N-acetylglucosaminyltransferase |
| fu | STK36 | Serine/threonine-protein kinase 36 |
| fz | FZD1 | Frizzled-1 |
| Gadd45 | GADD45G | |
| garz | GBF1 | BFA-resistant GEF 1 |
| Gbeta76C | GNB3 | |
| Gef26 | RAPGEF2 | |
| gish | CSNK1G3 | Casein kinase I isoform gamma-3 |
| gl | transcription factor | |
| GluRIIB | GRIK4 | |
| gsb-n | PAX3 | |
| Hem | NCKAP1 | Nck-associated protein 1 |
| hep | MAP2K7 | MAP kinase |
| hh | DHH | Desert hedgehog protein |
| hippo | STK3 | |
| hiw | MYCBP2 | E3 ubiquitin-protein ligase MYCBP2 |
| HLH4C | LYL1 | Lymphoblastic leukemia-derived sequence 1 |
| HLHm3 | HES6 | |
| HLHMgamma | HES2 | Transcription factor HES-2 |
| Hnf4 | HNF4A | |
| HP1c | CPX5 | HP1 |
| Hrb98DE | HNRNPA2B1 | Heterogeneous nuclear ribonucleoprotein |
| Hsf | HSF1 | Hsf |
| inx2 | gap junction | |
| IP3K1 | ITPKA | |
| klar | ||
| Lam | LMNB1 | Lamin-B1 |
| lbk | LRIG3 | LRR/Ig |
| Lim3 | LHX3 | |
| lin19 | CUL1 | |
| Lis-1 | PAFAH1B1 | Lissencephaly-1 |
| Lkr | TACR3 | Neuropeptide Y receptor related |
| Lmpt | FHL2 | |
| lz | RUNX3 | |
| mago | MAGOHB | RNA binding |
| mbl | MBNL1 | RNA binding |
| mib1 | MIB1 | E3 ubiquitin-protein ligase MIB1 |
| Mlc2 | MLY2 | |
| mol | DUOXA1 | Dual oxidase maturation factor 1 |
| msn | MAP4K4 | JNK pathway |
| msps | CKAP5 | |
| MstProx | TLR7 | |
| Mtch | MTCH2 | Mitochondrial carrier homolog 2 |
| mtTFB2 | TFB2M | |
| mxc | NPAT | activates histone transcription during cell cycle |
| N | NOTCH1 | |
| NaCP60E | SCN8A | |
| net | ATOH8 | transcription factor, atonal related |
| neur | NEURL1B | E3 ubiquitin-protein ligase NEURL3 |
| ninaE | OPN4 | |
| Nplp3 | ||
| nuf | RAB11FIP4 | Rab11 family-interacting protein 4 |
| nvy | CBFA2T3 | |
| Obp44a | ||
| okr | RAD54L | RAD54-like |
| Or98b | ||
| osk | ||
| Pis | CDIPT | Phosphatidylinositol synthase |
| pncr002:3R | ||
| Porin2 | VDAC3 | |
| Pp4–19C | PPP4C | Serine/threonine-protein phosphatase 4 |
| ppk21 | ASIC3 | |
| Psn | PSEN1 | |
| ptc | PTCH1 | |
| Rab9 | RAB9B | |
| Rala | RALA | Ras-related protein Ral-A |
| Ras85D | HRAS | HRas |
| rdgB | PITPNM2 | |
| RhoGEF2 | ARHGEF12 | |
| RhoGEF3 | SPATA13 | |
| ro | GBX2 | transcription factors |
| rok | ROCK1 | Rho-associated protein kinase 1 |
| Rph | RPH3A | Rabphilin-3A |
| rpk | ASIC2 | Na channel |
| Rya-r44F | RYR2 | Ryanodine receptor 2 |
| sals | SCAF1 | actin binding |
| santa-maria | CD36 | scavenger receptor |
| scrib | LRRC1 | |
| sec6 | EXOC3 | |
| sev | ROS1 | |
| Sfmbt | MBTD1 | MBT domain-containing protein 1 |
| shg | CDH20 | cadherin |
| snRNP-U1 | SNRPC | |
| Sod | SOD1 | |
| spi | TRADD | |
| Stam | STAM | |
| Stat92E | STAT5B | |
| sty | SPRY3 | EGFR signaling |
| Syt1 | SYT1 | |
| Syt14 | SYT14 | |
| Syt4 | SYT4 | |
| Tango14 | NUS1 | Nogo-B receptor Precursor |
| Tao-1 | TAOK1 | Serine/threonine-protein kinase TAO1 |
| Tim8 | TIMM8B | |
| Tm2 | TPM3 | Tropomyosin alpha-3 chain |
| TrpA1 | TRPA1 | |
| trr | MLL3 | Histone-lysine N-methyltransferase MLL3 |
| usnp | SNAP29 | Synaptosomal-associated protein 29 |
| vap | RASA1 | Ras GTPase-activating protein 1 |
| Vap-33-1 | VAPB | VAMP-B |
| Vps36 | VPS36 | |
| Vps37A | VPS37A | ESCRT |
| WASp | WASL | N-WASP |
| wdb | PPP2R5E | PP2A, B subunit |
| woc | ZMYM4 | zinc finger, MYM-type 4 |
| wtrw | TRPV1 | calcium channel |