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Our study suggests that Retriever could use the same SNX17-binding pocket (SBP) to interact with additional factors. The interaction with SNX17 tethers Retriever to many cargoes recognized by SNX17 through NPxY/NxxY motifs in their cytoplasmic tails (left), while the interaction with other factors can potentially link Retriever to distinct cargoes, recycling pathways, or cellular destinations (right).
