Table 1.

Quantitative analysis of the amyloid-β species in the coronal brain sections of 5XFAD mice, depicted by the FAM-labeled E3 nanobody.

Brain Regions	Number of Animals	Number of observed brain slides	Total number of Abeta populations		Density (number/mm2)		Abeta Area (μm2)		Average Size in Diameter of Abeta-associated FAM-E3a (μm)		Eccentricity
			Average	S.D.	Average	S.D.	Average	S.D.	SAβO	Plaques	Average	S.D.
Cortex	3	21	131.86	51.69	89.72	38.28	68.23	123.96	2	14	0.52	0.28
Hippocampus	3	6	63.00	62.61	38.87	34.74	41.01	87.95			0.57	0.27
Hypothalamus	3	6	296.50	7.78	170.90	3.10	47.69	77.34			0.63	0.23
Thalamus	3	6	207.75	78.49	122.44	46.68	43.92	78.02			0.53	0.29

^aDetermined using ImageJ.