Table 1.
Characteristics of the whole study population
| Characteristics | Total n=182 | Chicago version 3.0 n=97 (53.3) | Chicago version 4.0 n=85 (46.7) | P |
|---|---|---|---|---|
| Age, median (IQR), yrs | 38 (29–53) | 39 (33–54) | 37 (29–50) | 0.29a |
| Sex, no. (%) | ||||
| Men | 102 (56) | 53 (54.6) | 49 (57.6) | 0.76b |
| Women | 80 (44) | 44 (45.4) | 36 (42.4) | |
| Indication of HRM, no. (%) | 0.02b | |||
| Atypical GERD symptoms | 17 (9.3) | 11 (11.3) | 6 (7.1) | |
| Dysphagia | 61 (23.6) | 17 (17.5) | 26 (30.6) | |
| GERD unresponded to medications | 89 (48.9) | 56 (57.7) | 33 (38.8) | |
| NCCP | 3 (1.6) | — | 3 (3.5) | |
| Odynophagia | 2 (1.1) | 1 (1) | 1 (1.2) | |
| Pre-fundoplication | 28 (15.4) | 12 (12.4) | 16 (18.8) | |
| Symptoms, no. (%) | ||||
| Atypical GERD symptoms | 38 (20.9) | 23 (23.7) | 15 (17.6) | 0.3b |
| Chest pain | 17 (9.3) | 11 (11.3) | 6 (7.1) | 0.4b |
| Dysphagia | 67 (36.8) | 31 (32) | 36 (42.3) | 0.1b |
| Typical GERD symptoms | 143 (78.6) | 78 (80.4) | 65 (76.5) | 0.5b |
| Chronic PPI usage? no. (%) | ||||
| No | 29 (15.9) | 12 (12.8) | 17 (20) | 0.2b |
| Yes | 153 (84.1) | 85 (87.6) | 68 (80) | |
| PPI dosage, no. (%) | <0.001b | |||
| 20 mg OD | 35 (22.9) | 10 (11.8) | 25 (36.7) | |
| 40 mg OD | 52 (34) | 23 (27.1) | 29 (42.6) | |
| 20 mg BID | 37 (24.2) | 26 (30.6) | 11 (16.2) | |
| 40 mg BID | 29 (19) | 26 (30.6) | 3 (4.4) |
BID: twice daily; GERD: gastroesophageal reflux disease; HRM: high-resolution manometry; LES: lower esophageal sphincter; NCCP: noncardiac chest pain; PPIs: proton pump inhibitors; OD: once daily. a—Mood’s test with the exact calculation. b—Fisher’s exact test