Table 3.
Sensitivity, specificity, positive, and negative predictive values of symptomatic variables for major esophageal motility disorders
| Symptoms (95% CI) | Sensitivity | P | Specificity | P | Positive predictive value | P | Negative predictive value | P | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|
|||||||||||||
| Overall | Chicago 3.0 | Chicago 4.0 | Overall | Chicago 3.0 | Chicago 4.0 | Overall | Chicago 3.0 | Chicago 4.0 | Overall | Chicago 3.0 | Chicago 4.0 | |||||
| Atypical GERD symptomsa | 20.7 (13.6—29.5) | 29.3 (18.1—42.7) | 11.3 (4.27—23) | 0.03 | 78.9 (67.6—87.7) | 84.6 (69.5—94.1) | 71.9 (53.3—86.3) | 0.2 | 60.5 (43.4—76) | 73.9 (51.6—89.8) | 40 (16.3—67.7) | 0.04 | 38.9 (30.9—47.4) | 44.6 (33—56.6) | 32.9 (22.1—45.1) | 0.1 |
| Dysphagia | 41.1 (32.2—51.2) | 36.2 (24—49.9) | 47.2 (33.3—61.4) | 0.2 | 70.4 (58.4—80.7) | 74.4 (57.9—87) | 65.6 (46.8—81.4) | 0.4 | 68.7 (56.2—79.4) | 67.7 (48.6—83.3) | 69.4 (51.9—83.7) | 1 | 43.5 (34.3—53) | 43.9 (31.7—56.7) | 42.9 (28.8—57.8) | 1 |
| Noncardiac chest pain | 9 (4.4—15.9) | 12.1 (4.99—23.3) | 5.66 (1.18—15.7) | 0.3 | 90.1 (80.7—95.5) | 89.7 (75.8 —97.1) | 90.6 (75—98) | 1 | 58.8 (32.9—81.6) | 63.6 (30.8—89.1) | 50 (11.8—88.2) | 0.6 | 38.8 (31.3—46.7) | 40.7 (30.2—51.8) | 36.7 (26.1—48.3) | 0.6 |
| Typical GERD symptomsb | 73.9 (64.7—81.8) | 81 (68.6—90.1) | 66 (51.7—78.5) | 0.08 | 14.1 (6.97—24.4) | 20.5 (9.3—36.5) | 6.25 (0.76—20.8) | 0.1 | 57.3 (48.8—65.6) | 60.3 (48.5—71.2) | 53.8 (41—66.3) | 0.4 | 25.6 (13—42.1) | 42.1 (20.3—66.5) | 10 (1.23—31.7) | 0.03 |
GERD: gastroesophageal reflux disease. a—Atypical GERD symptoms include any of the following: change voice, cough, globus sensation, or throat clearing. b—Typical GERD symptoms include heartburn, regurgitation, or both of them