Table 2.
Genes Associated With Maturation Failure in Pre-Access Veins as Determined Using RNA Sequencing
| Gene Symbol | Gene Name | Chromosomal Location | Log2(FC) | Log2(CPM) | P | FDR |
|---|---|---|---|---|---|---|
| PF4 | Platelet factor 4 | 4q13.3 | 3.47 | 1.58 | 1.33 × 10−06 | 0.016 |
| FPR1 | Formyl peptide receptor 1 | 19q13.41 | 2.40 | 3.02 | 1.82 × 10−06 | 0.016 |
| VNN2 | Vanin 2 | 6q23.2 | 2.66 | 2.82 | 2.73 × 10−06 | 0.016 |
| S100A9 | S100 calcium binding protein A9 | 1q21.3 | 2.88 | 5.10 | 6.32 × 10−06 | 0.022 |
| CSF3R | Colony-stimulating factor 3 receptor | 1p34.3 | 2.34 | 3.95 | 6.58 × 10−06 | 0.022 |
| AC006262.6 | Uncharacterized lincRNA | 19q13.32 | −1.78 | −0.16 | 7.99 × 10−06 | 0.022 |
| CXCR1 | C-X-C motif chemokine receptor 1 | 2q35 | 3.02 | 1.66 | 8.76 × 10−06 | 0.022 |
| S100A8 | S100 calcium-binding protein A8 | 1q21.3 | 2.89 | 3.85 | 3.18 × 10−05 | 0.056a |
Note: Change in gene expression is expressed as log2 of the fold change in the failed subgroup with respect to the matured subgroup. Expression levels are expressed as log2 of counts per million.
Abbreviations: FDR, false discovery rate; lincRNA, long intergenic noncoding RNA.
a
Despite an FDR > 0.05, S100A8 was selected for further confirmatory analyses due to its biological function as dimer partner of S100A9 and its borderline statistical significance.