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. 2024 Mar 29;11(2):024208. doi: 10.1117/1.NPh.11.2.024208

Fig. 1.

Fig. 1

Luminopsin (LMO) features. (a) The luciferase-opsin fusion molecule (luminopsin) enables bimodal chemogenetic (CTZ) and optogenetic (LED) access to opsin activation. (b) Parameters for improving LMO performance are brightness of the light emitter, light sensitivity of the light sensor, and matching spectra for peak light emission and sensing. Moieties used in this study are indicated. (c) Possibilities for arrangement of moieties are N-terminal, C-terminal, or N- and C-terminal fusion of the luciferase to the opsin.