Table 4.

Results of subgroup analysis of RFS.

Subgroup	No. of studies	HR (95% CI)	P	Heterogeneity		Model
				I2 (%)	Ph
Treatment
With-surgery	4	1.38 (1.07–1.77)	.012	69.5	0.02	Random
Immunotherapy	2	2.55 (0.75–8.66)	.134	94.1	<0.001	Random
Country
China	4	2.34 (1.32–4.16)	.004	82.6	0.001	Random
Non-China	2	1.15 (1.05–1.26)	.003	0	0.468	Fixed
Sample size
>1000	2	1.15 (1.05–1.26)	.003	0	0.468	Fixed
<1000	4	2.34 (1.32–4.16)	.004	82.6	0.001	Random
Cuf-off
≥507	2	2.39 (0.62–9.16)	.204	95.7	<0.001	Random
<507	3	1.63 (1.28–2.07)	<.001	37.4	0.202	Fixed
NR	1	1.13 (1.02–1.26)	.025	–	–	–
NOS
8	1	4.85 (2.89–8.14)	<.001	–	–	–
9	5	1.36 (1.11–1.66)	.003	63	0.029	Random

95% CI = 95% confidence interval, HR = hazard ratio, NOS = Newcastle-Ottawa Scale, NR = not reported, RFS = recurrence-free survival.