Table 3.
Treatment-related adverse reactions.
| Side effect | RCT | NRCT | Cohort study |
|---|---|---|---|
| Estimate (95% CI) | Estimate (95% CI) | Estimate (95% CI) | |
| Myelosuppression | — | OR 1.26 (0.75–2.09) | OR 1.15 (0.19–6.94) |
| Leukopenia | OR 0.78 (0.24–2.49) | — | — |
| Neutropenia | OR 0.36(0.15–0.85)* | — | — |
| Thrombocytopenia | OR 1.08 (0.55–2.14) | OR 0.71 (0.20–2.51) | — |
| Anemia | OR 0.72 (0.28–1.81) | OR 0.75 (0.23–2.44) | — |
| Bleeding | OR 1.68 (0.63–4.49) | — | — |
| cardiovascular toxicity | OR 6.60 (0.77–56.65) | — | — |
| Liver and kidney dysfunction | OR 0.79 (0.21–3.03) | OR 1.10 (0.58–2.09) | — |
| Neurotoxicity | — | — | OR 1.75 (0.56–5.48) |
| Gastrointestinal reaction | OR 0.80 (0.37–1.71) | OR 1.24 (0.74–2.10) | OR 2.15 (0.42–11.03) |
| Nausea | OR 0.74 (0.32–1.68) | — | — |
| Vomiting | OR 0.85 (0.34–2.10) | — | — |
| Diarrhea | OR 0.81 (0.45–1.46) | — | OR 4.53 (1.60–12.84)** |
| Radiation proctitis | OR 1.67 (0.49–5.72) | OR 0.95 (0.47–1.91) | OR 0.25 (0.10–0.66)** |
| Radiation cystitis | OR 2.29 (0.20–26.22) | OR 1.00 (0.18–5.51) | — |
| Rash | OR 1.49 (0.55–4.04) | — | — |
| Fever | OR 1.67 (0.42–6.61) | — | — |
| Alopecia | OR 1.46 (0.43–4.93) | OR 0.78 (0.25–2.39) | OR 2.89 (0.91–9.17) |
| Hypertension | OR 10.80 (1.25–93.44)* | — | — |
| Genitourinary tract reaction | OR 1.22 (0.14–11.01) | OR 0.87 (0.30–2.48) | OR 1.50 (0.27–8.28) |
CI = confidence interval, NRCT = nonrandomized controlled trial, OR = odds ratio, RCT = randomized controlled trial.
*P < 0.05, **P < 0.01.