TABLE 4.
Prevalence of infectious virus and viral DNA in tissues of F344 rats after o.n. inoculation with RPV-1a as determined by ISH
| Tissue | Results of ISH at indicated PIDa
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Infants
|
Weanlings
|
|||||||
| 5 | 7 | 10 | 20 | 5 | 7 | 10 | 20 | |
| Lung | − | − | • | • | ||||
| Kidney | •• | • | •• | • | − | |||
| Spleen | • | • | •• | • | − | |||
| Lymph nodes | •• | •• | •• | ••• | ••• | ••• | • | |
| Thymus | − | − | •• | − | − | |||
| Liver | •• | • | • | − | ||||
| Small intestine | •• | •• | •• | • | ••• | ••• | •• | − |
| Brain | − | • | • | − | ||||
| Heart | − | • | •• | − | − | |||
a
Number of cells per low-power field: −, negative; , trace (1 to 5 cells); •, low (6 to 10 cells); •• moderate (11 to 20 cells); •••, high (>20 cells). Apart from a few infected endothelial cells, salivary glands, pancreas, large intestine, gonads were negative in infants and weanlings.