Table 2.

A complete list showing all differential expressed protein identified with mass spectrometry between PND and non-PND cerebrospinal fluid samples.

Protein	Number	Accession	Regulated-stage	BLAST score	N75-vs-N79	N111-vs-N79	Description
P22392	1	P22392	Down	317	0.41	0.58	Nucleoside diphosphate kinase B
P61978	2	P61978	Down	940	0.48	0.61	Heterogeneous nuclear ribonucleoprotein K
O75541	3	O75541	Down	738	0.30	0.42	Zinc finger protein 821
Q8NGH9	4	Q8NGH9	Down		0.49	0.35	Olfactory receptor 52E4
P06748	5	P06748	Down	598	0.24	0.26	Nucleophosmin
B2RPK0	6	B2RPK0	Down	321	0.31	0.48	Putative high mobility group protein B1-like 1
Q9GZV4	7	Q9GZV4	Down	317	0.35	0.33	Eukaryotic translation initiation factor 5A-2
Q6NXT2	8	Q6NXT2	Down	258	0.48	0.52	Histone H3.3C
P02652	9	P02652	Down		0.88	0.80	Apolipoprotein A-II
P02654	10	P02654	Down		0.59	0.60	Apolipoprotein C-I
Q9UM44	11	Q9UM44	Down		0.15	0.17	HERV-H LTR-associating protein 2
Q14847	12	Q14847	Down	550	0.44	0.68	LIM and SH3 domain protein 1
P30101	13	P30101	Down	1044	0.32	0.38	Protein disulfide-isomerase A3
P27797	14	P27797	Down	839	0.38	0.39	Calreticulin
P19823	15	P19823	Down	173	0.74	0.77	Inter-alpha-trypsin inhibitor heavy chain H2
P11021	16	P11021	Down	1326	0.31	0.34	Endoplasmic reticulum chaperone BiP
P05062	17	P05062	Down	759	0.60	0.60	Fructose-bisphosphate aldolase B
O60814	18	O60814	Down	254	0.42	0.29	Histone H2B type 1-K
P01876	19	P01876	Down		0.72	0.74	Immunoglobulin heavy constant alpha 1
P08708	20	P08708	Down	276	0.35	0.71	40S ribosomal protein S17
P38646	21	P38646	Down	1392	0.34	0.40	Stress-70 protein, mitochondrial
P37198	22	P37198	Down	1025	0.32	0.42	Nuclear pore glycoprotein p62
P07737	23	P07737	Down	291	0.60	0.71	Profilin-1
P62913	24	P62913	Down	366	0.40	0.46	60S ribosomal protein L11
P10809	25	P10809	Down	1139	0.30	0.38	60 kDa heat shock protein, mitochondrial
P07237	26	P07237	Down	1037	0.39	0.49	Protein disulfide-isomerase
P58304	27	P58304	Down	453	0.26	0.29	Visual system homeobox 2
Q93088	28	Q93088	Down	839	0.46	0.60	Betaine--homocysteine S-methyltransferase 1
P02647	29	P02647	Down		0.76	0.69	Apolipoprotein A-I
P05787	30	P05787	Down		0.31	0.20	Keratin, type II cytoskeletal 8
P04114	31	P04114	Down	9381	0.67	0.69	Apolipoprotein B-100
P01861	32	P01861	Down		0.78	0.66	Immunoglobulin heavy constant gamma 4
P42765	33	P42765	Down	811	0.20	0.21	3-ketoacyl-CoA thiolase, mitochondrial
Q9NU22	34	Q9NU22	Down	4065	0.55	0.75	Midasin
Q8WWF5	35	Q8WWF5	Down	852	0.40	0.42	E3 ubiquitin-protein ligase ZNRF4
P60174	36	P60174	Down	511	0.27	0.29	Triosephosphate isomerase
Q32P51	37	Q32P51	Down	642	0.60	0.76	Heterogeneous nuclear ribonucleoprotein A1-like 2
P14927	38	P14927	Down	225	0.35	0.36	Cytochrome b-c1 complex subunit7
Q86XE5	39	Q86XE5	Down	247	0.30	0.29	4-hydroxy-2-oxoglutarate aldolase, mitochondrial
P23528	40	P23528	Down	335	0.51	0.49	Cofilin-1
Q96PQ6	41	Q96PQ6	Down	1242	0.43	0.42	Zinc finger protein 317
Q15493	42	Q15493	Down	625	0.34	0.36	Regucalcin
P31327	43	P31327	Down	3108	0.47	0.49	Carbamoyl-phosphate synthase [ammonia], mitochondrial
P62937	44	P62937	Down	339	0.40	0.43	Peptidyl-prolyl cis-trans isomerase A
P46779	45	P46779	Down	278	0.58	0.58	60S ribosomal protein L28
P02763	46	P02763	Up		1.49	1.68	Alpha-1-acid glycoprotein 1
P02766	47	P02766	Up	302	1.24	1.88	Transthyretin
P02042	48	P02042	Up	303	1.43	1.93	Hemoglobin subunit delta
Q6P587	49	Q6P587	Up	463	1.23	1.49	Acylpyruvase FAHD1, mitochondrial
P02748	50	P02748	Up		1.23	1.34	Complement component C9
Q5SYB0	51	Q5SYB0	Up	3243	1.74	2.10	FERM and PDZ domain-containing protein 1
Q12805	52	Q12805	Up	1019	1.33	1.35	EGF-containing fibulin-like extracellular matrix protein 1
Q16270	53	Q16270	Up		1.27	1.66	Insulin-like growth factor-binding protein 7
P10643	54	P10643	Up		1.38	1.36	Complement component C7
P69905	55	P69905	Up	286	1.48	2.33	Hemoglobin subunit alpha
Q13822	56	Q13822	Up	1775	1.31	1.53	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
P36222	57	P36222	Up	797	1.25	1.25	Chitinase-3-like protein 1
P07998	58	P07998	Up		1.28	1.33	Ribonuclease pancreatic
P51693	59	P51693	Up	1313	1.29	1.21	Amyloid-like protein 1
P05090	60	P05090	Up	393	1.29	1.61	Apolipoprotein D
P36955	61	P36955	Up	704	1.34	1.62	Pigment epithelium-derived factor
P36956	62	P36956	Up	2288	1.50	2.04	Sterol regulatory element-binding protein 1
P01009	63	P01009	Up	856	1.23	1.96	Alpha-1-antitrypsin
P61769	64	P61769	Up		1.78	2.20	Beta-2-microglobulin
Q9Y6V0	65	Q9Y6V0	Up		1.65	2.61	Protein piccolo
Q9GZU2	66	Q9GZU2	Up	3306	1.63	1.31	Paternally-expressed gene 3 protein
P23142	67	P23142	Up	1424	1.40	1.63	Fibulin-1
P06396	68	P06396	Up	1621	1.22	1.39	Gelsolin
Q8N960	69	Q8N960	Up		1.24	1.84	Centrosomal protein of 120 kDa
P08603	70	P08603	Up		1.20	1.24	Complement factor H
P10909	71	P10909	Up		1.44	1.49	Clusterin
Q15113	72	Q15113	Up	914	1.41	1.32	Procollagen C-endopeptidase enhancer 1
P01033	73	P01033	Up	432	1.62	1.67	Metalloproteinase inhibitor 1
P01034	74	P01034	Up		1.36	1.37	Cystatin-C
Q16610	75	Q16610	Up		1.33	1.26	Extracellular matrix protein 1
P68871	76	P68871	Up	301	1.65	2.49	Hemoglobin subunit beta
P00746	77	P00746	Up	457	1.45	1.29	Complement factor D
P02774	78	P02774	Up		1.31	1.42	Vitamin D-binding protein
Q8WXW3	79	Q8WXW3	Up		1.34	1.67	Progesterone-induced-blocking factor 1
P02675	80	P02675	Up	1030	1.37	1.65	Fibrinogen beta chain
P41222	81	P41222	Up	49.3	1.38	1.54	Prostaglandin-H2 D-isomerase
A0A1B0GW35	82	A0A1B0GW35	Up	74.3	1.71	1.49	Exocyst complex component 1-like
P17900	83	P17900	Up		1.37	1.29	Ganglioside GM2 activator
P08294	84	P08294	Up	491	1.38	1.30	Extracellular superoxide dismutase [Cu-Zn]
Q92876	85	Q92876	Up	508	1.28	1.45	Kallikrein-6

PND = perioperative neurocognitive dysfunction.