Table 4.
KEGG pathway analysis of 8 selected DEPs including HMGB1, APOA, APOC, NPM, PTGDS, KLK6, TIMP1, and TTR.
| Pathway ID | Pathway_Name | Diff-mapping | Protein-Mapping | Diff-Num | Protein-Num | Fold-Enrichment | Fisher exact test P value | Mapping -Protein IDs |
|---|---|---|---|---|---|---|---|---|
| map04610 | Complement and coagulation cascades | 10 | 37 | 28 | 227 | 2.19 | 0.01 | P10909; P05546; P00746; P01009; P02675; P08603; P01042; P10643; P00734; P02748 |
| map05144 | Malaria | 2 | 3 | 28 | 227 | 5.40 | 0.04 | P68871; P69905 |
| map04080 | Neuroactive ligand-receptor interaction | 2 | 3 | 28 | 227 | 5.40 | 0.04 | P00734; P07477 |
| map04977 | Vitamin digestion and absorption | 3 | 3 | 65 | 227 | 3.49 | 0.02 | P04114; P02647; P06727 |
| map04141 | Protein processing in endoplasmic reticulum | 4 | 6 | 37 | 227 | 4.09 | 0.01 | P30101; P27797; P11021; P07237 |
| map05034 | Alcoholism | 3 | 5 | 37 | 227 | 3.68 | 0.03 | O60814;Q6NXT2; P62805 |
APOA = apolipoprotein A-II, APOC = apolipoprotein C-I, DEP = differential expressed protein, HMGB1 = High Mobility Group Box 1, KEGG = Kyoto Encyclopedia of Genes and Genomes, KLK6 = Kallikrein-6, NPM = nucleophosmin, PTGDS = prostaglandin D synthase, TIMP = matrix metalloproteinase inhibitor, TTR = transthyretin.