Table 3.
Crude and adjusted odds ratios (95% CI) of increased 10-year risk scores (≥5%) for atherosclerotic cardiovascular disease in postmenopausal women according to oral glucose tolerance status.
| NGT | IGT | IPH | |
|---|---|---|---|
| Scenario 1† | |||
| No. of subjects (10-yr ASCVD risk score ≥5% vs <5%) | 15/121 | 43/171 | 25/53 |
| Model 1 | 1.0 | 2.03 (1.08–3.82)* | 3.81 (1.86–7.79)*** |
| Model 2 | 1.0 | 1.92 (1.01–3.62)* | 3.35 (1.62–6.92)** |
| Model 3 | 1.0 | 1.96 (0.98–3.89) | 3.28 (1.47–7.36)** |
| Scenario 2‡ | |||
| No. of subjects (10-yr ASCVD risk score ≥5% vs <5%) | 15/121 | 43/171 | 56/22 |
| Model 1 | 1.0 | 2.03 (1.08–3.82)* | 20.53 (9.91–42.55)*** |
| Model 2 | 1.0 | 1.89 (0.99–3.58) | 19.03 (9.08–39.90)*** |
| Model 3 | 1.0 | 1.87 (0.93–3.78) | 26.74 (11.47–62.34)*** |
Data are expressed odds ratios (95% CI).
Model 1, no adjustment; Model 2, further adjusted for BMI; Model 3, further adjusted for physical inactivity score, Log ALT, serum Cr, hypertension treatment (yes vs no), and Hormone replacement (yes vs no).
ALT = alanine aminotransferase, ASCVD = atherosclerotic cardiovascular disease, BMI = body mass index, CI = confidence intervals, Cr = creatinine, IGT = impaired glucose tolerance, IPH = isolated postchallenge hyperglycemia, Log ALT = logarithmic transformation of ALT (in U/L), NGT = normal glucose tolerance.
Scenario 1: subjects with IPH were not designated as patients of diabetes mellitus while performing ASCVD risk estimation.
Scenario 2: subjects with IPH were designated as patients of diabetes mellitus while performing ASCVD risk estimation.
P < .05 versus NGT by logistic regression analysis.
P < .01 versus NGT by logistic regression analysis.
P < .0001 versus NGT by logistic regression analysis.