Table 2.
Comparison of diagnostic performance among static CTP and dynamic CTP on per-vessel analysis.
| Parameters | TP | TN | FP | FN | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Diagnostic accuracy (%) | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Static CTP | ||||||||||
| Visual analysis | 8 | 103 | 2 | 12 | 40.0 (19.1–63.9) | 98.1 (93.3–99.8) | 80.0 (47.8–94.6) | 89.6 (85.7–92.5) | 88.8 (81.9–93.7) | 0.690 (0.602–0.770) |
| Quantitative analysis (myocardial attenuation ≤82 HU) | 9 | 92 | 13 | 11 | 45.0 (23.1–68.5) | 87.6 (79.8–93.2) | 40.9 (25.5–58.3) | 89.3 (84.8–92.6) | 80.8 (72.8–87.3) | 0.663 (0.573–0.745) |
| Combined visual and quantitative analysis | 11 | 92 | 13 | 9 | 55.0 (32.5–76.9) | 87.6 (79.8–93.2) | 45.8 (30.7–61.7) | 91.1 (86.2–94.3) | 82.4 (74.6–88.6) | 0.713 (0.625–0.790) |
| Dynamic CTP | ||||||||||
| Visual analysis | 10 | 103 | 2 | 10 | 50.0 (27.2–72.8) | 98.1 (93.3–99.8) | 83.3 (54.2–95.5) | 91.2 (86.9–94.1) | 90.4 (83.8–94.9) | 0.740 (0.654–0.815) |
| Quantitative analysis (MBF ≤ 101 mL/100 mL/min) |
15 | 82 | 23 | 5 | 75.0 (50.9–91.3) | 78.1 (69.0–85.6) | 39.5 (29.6–50.3) | 94.3 (88.4–97.2) | 77.6 (69.3–84.6) | 0.765 (0.681–0.837) |
| Combined visual and quantitative analysis | 16 | 82 | 23 | 4 | 80.0 (56.3–94.3) | 78.1 (69.0–85.6) | 41.0 (31.3–51.5) | 95.3 (89.5–98.0) | 78.4 (70.2–85.3) | 0.790 (0.709–0.858) |
| Static CTP vs Dynamic CTP | ||||||||||
| P value (visual analysis) | .530 | 1.000 | .845 | .683 | .558 | .546 | ||||
| P value (quantitative analysis) | .056 | .069 | .994 | .217 | .534 | .203 | ||||
| P value (combined visual and quantitative analysis) | .096 | .069 | .786 | .259 | .426 | .312 |
AUC = area under the curve, CTP = computed tomography perfusion, FN = false negative, FP = false positive, MBF = myocardial blood flow, NPV = negative predictive value, PPV = positive predictive value, TN = true negative, TP = true positive.