Table 3.
Adverse events on RTX in neuromyelitis optica spectrum disorders.
| Study | Total number of patients | Number of patients with adverse events | Adverse events | Number of events | Total number of discontinuation due to adverse effects |
|---|---|---|---|---|---|
| Cabre 2018 | 32 | 7 | Lower urinary tract infection | 1 | 1 |
| Pharyngitis | 1 | ||||
| Xerostomia | 1 | ||||
| Moderate headache | 1 | ||||
| Moderate fever | 1 | ||||
| Laryngeal dysesthesia | 1 | ||||
| Fernández-Megía 2015 | 6 | 2 | Infusion reactions | 2 | – |
| Jacob 2008 | 25 | 12 | Infusion reactions | 7 | – |
| Herpes simplex and positive tuberculin skin test herpes zoster | 1 | ||||
| Recurrent Clostridium difficile colitis | 1 | ||||
| A cutaneous fungal infection | 1 | ||||
| Fatal urinary tract–related septicemia | 1 | ||||
| 1 | |||||
| Kim 2015 | 100 | 34 | Infusion-related reactions | 26 | – |
| Herpes zoster infection | 5 | ||||
| Pneumonia | 2 | ||||
| Thyroid cancer | 1 | ||||
| Nikoo 2017 | 33 | 4 | Allergic reactions | 4 | 1 |
| Shaygannejad 2019 | 44 | 15 | Infusion reactions | 14 | 1 |
| Severe allergic reaction | 1 | ||||
| Zephir 2015 | 32 | 0 | No relevant side effect | 0 | – |
| Zhang 2017 | 31 | 4 | Infusion reactions | 4 | – |
| Annovazzi 2016 | 73 | 19 | Urinary tract infections | 6 | 2 |
| Respiratory infections | 4 | ||||
| Infusion reactions | 7 | ||||
| Died | 2 | ||||
| Pellkofer 2011 | 9 | 4 | Urogenital infection, thrombosis, death | 1 | – |
| Adnexitis | 1 | ||||
| Pneumonia | 1 | ||||
| Urosepsis | 1 | ||||
| Ip 2013 | 7 | 2 | Infusion reactions | 2 | – |
| Yang 2018 | 20 | 1 | Transit hyperpyrexia | 1 | – |
| Bedi 2011 | 23 | 7 | Herpes zoster infection | 1 | – |
| Urinary tract infection | 1 | ||||
| Respiratory infections | 2 | ||||
| Fatigue | 1 | ||||
| Transient leukopenia | 1 | ||||
| Transient elevations of hepatic transaminases | 1 | ||||
| Casallas-Vanegas 2020 | 66 | 3 | Respiratory infections | 2 | – |
| Urinary tract infection | 1 | ||||
| Flores 2012 | 13 | 3 | Tetter | 3 | – |
| Kim 2013 | 30 | 12 | Infusion reactions | 12 | – |
| Lin 2018 | 14 | 2 | Phthisis | 1 | 1 |
| Respiratory infections | 1 | ||||
| Wu 2019 | 15 | 3 | No clear | – | |
| Xiao 2020 | 36 | 8 | Infusion reactions | 5 | – |
| Urinary tract infection | 3 | ||||
| Jia 2018 | 9 | 2 | Infusion reactions | 1 | – |
| Herpes zoster infection | 1 | ||||
| Niu 2019 | 15 | 1 | Respiratory infections | 1 | – |
| Wang 2018 | 21 | 8 | No clear | – | |
| Zhang 2016 | 19 | 1 | Herpes zoster infection | 1 | – |
| Zhu 2018 | 8 | 2 | Infusion reactions | 2 | – |