Table 2.

Clinical, diagnostic, and therapeutic differences between erythema nodosum and Sweet syndrome

	Erythema nodosum	Sweet syndrome
Clinical features	• More common in women associated with arthritis and active disease18,20 • Sudden onset, erythematous, warm, painful, non-ulcerative nodules of 1–5 cm in diameter19 • Commonly seen in extensor surfaces of lower limbs19	• More common in women of 3rd–5th decades of life22 • Painful erythematous plaques or nodules commonly seen on the face, neck, and upper limbs22 • Fever and leukocytosis with neutrophilia
Diagnosis	Clinical diagnosis or biopsy: Lymphohistiocytic infiltrate of the lower dermis21	Biopsy: Edema of the papillary dermis and dense neutrophilic infiltrate in the dermis22
Management	Pain management (NSAIDs, colchicine), systemic corticosteroids, immunosuppressive agents and resistant cases with infliximab20,21	Systemic corticosteroids, cyclosporine22