This study assessed a higher dose (180 mg) and an alternate injection site for RBP-7000 monthly risperidone injection in patients with schizophrenia stabilized on 6 mg/day oral risperidone. Plasma exposure data in combination with clinical efficacy measures support the conclusion that RBP-7000 180-mg dose approximates 6 mg/day oral risperidone. Administration of RBP-7000 at the back of the upper arm showed comparable exposure to administration in the abdomen with no clinically meaningful differences in safety or efficacy measures.