Table 2.

Analysis of variance of primary pharmacokinetic variables of fasudil

Parameter	n	LS mean		LS mean ratio (oral/IV treatment)
		treatment A (oral)	treatment B (IV)	Point estimate (%, 90% CI)	Intra-subject CV (%)
AUC0–tz (μg × h/L)	14	0.29	55.58	0.52 (0.31–0.87)	70.46
Cmax (μg/L)	14	1.41	100.65	1.41 (0.92–2.17)	56.92

AUC_0–tz area under the concentration time curve from zero up to the last measured concentration, C_max highest measured concentration determined in the measuring interval, CI confidence interval, CV coefficient of variation, LS, least square, n number of evaluable subjects included in the model. Results are based on a linear mixed-effects model with sequence, period, and treatment as fixed effects and subject nested within sequence as a random effect