FIG. 6.

ARF N-terminal peptides are specific inhibitors of cell-free poliovirus RNA replication. (A) ³⁵S-labeled translation and processing products from the cell-free system in the presence of the indicated concentrations of the P-13, P-26, and P-28 peptides. Products were resolved as for Fig. 1A. (B) RNA products from cell-free reactions containing 400 μM P-13, P-26, and P-28, plus an equivalent amount of HEPES buffer (800 μM) added with the peptides. Products were resolved as for Fig. 2B. (C) Viral yield from cell-free reactions containing indicated concentrations of P-13, P-26, and P-28 and 800 μM HEPES. Results are generally representative of several independent experiments.