Table 2.

Prevalence of non-motor symptoms in PRKN-PD (n = 152)^a

Non-motor symptoms	Frequency	Present	Absent	Missing data
Autonomic dysfunction	62.6%	n = 72b	n = 43c	n = 37
Orthostatic hypotension	28.4%	n = 29	n = 73	n = 50
Constipation	37.7%	n = 40	n = 66	n = 46
Urinary urgency	47.7%	n = 53	n = 58	n = 41
Sleep disturbance	72.5%	n = 87d	n = 33e	n = 32
Somnolence	37.8%	n = 42	n = 69	n = 41
Insomnia	63.5%	n = 73	n = 42	n = 37
RBD	29.4%	n = 32	n = 77	n = 43
Sleep apnoea	11.5%	n = 9	n = 69	n = 74
Restless legs syndrome	13.9%	n = 15	n = 93	n = 44
Olfactory dysfunction	18.5%	n = 12	n = 53	n = 87
Impulse control disorders or punding	21.4%	n = 24	n = 88	n = 40
Psychological disturbance	64.5%	n = 82f	n = 45g	n = 25
Apathy	11.8%	n = 13	n = 97	n = 42
Depression	40.5%	n = 49	n = 72	n = 31
Anxiety	49.5%	n = 59	n = 60	n = 33
Hallucinations	18.5%	n = 23	n = 101	n = 28
Psychosis	9.3%	n = 10	n = 97	n = 45
Cognitive impairment	20.8%	c = 20h	n = 76i	n = 56
Mild cognitive declinej	24.4%	n = 19	n = 59	n = 74
Dementia	1%	n = 1	n = 95	n = 56

^aSupplementary Fig. 5 depicts the flow chart demonstrating the number of patients included in assessing the prevalence of non-motor symptoms.

^bCases reporting the presence of any one of the following features of autonomic dysfunction: orthostatic hypotension, constipation or urinary urgency.

^cCases reporting the absence of all of the following features of autonomic dysfunction: orthostatic hypotension, constipation and urinary urgency.

^dCases reporting the presence of any one of the following features of sleep disturbance: somnolence, insomnia, RBD, sleep apnoea or restless legs syndrome.

^eCases reporting the absence of all of the following features of sleep disturbance: somnolence, insomnia, RBD, sleep apnoea and restless legs syndrome.

^fCases reporting the presence of any one of the following features of psychological disturbance: apathy, depression, anxiety, hallucinations or psychosis.

^gCases reporting the absence of all of the following features of psychological disturbance: apathy, depression, anxiety, hallucination and psychosis.

^hCases reporting the presence of mild cognitive decline or dementia.

ⁱCases reporting the absence of both mild cognitive decline and dementia.

^jAs defined by clinician’s opinion, or a MOCA < 26 or a MMSE < 25 in the 152 patients with detailed phenotypic information. Objective evidence of mild cognitive decline, with a MMSE < 25 (n = 253, Supplementary Fig. 1) was noted in 6% of cases.