Table 5.
The top 30 adverse events of Alprazolam ranked by case reports.
| SOC | PTs | Case reports | ROR (95% CI) | PRR (95% CI) | χ2 | IC (IC025) | EBGM (EBGM05) |
|---|---|---|---|---|---|---|---|
| Psychiatric disorders | Drug abuse | 3836 | 39.45 (38.15–40.78) | 37.53 (36.36–38.75) | 129,025.80 | 5.14 (5.09) | 35.51 (34.34) |
| Injury, poisoning and procedural complications | Toxicity to various agents | 1943 | 8.74 (8.35–9.14) | 8.54 (8.17–8.93) | 12,807.38 | 3.07 (3.01) | 8.44 (8.07) |
| Psychiatric disorders | Completed suicide | 1342 | 12.23 (11.58–12.91) | 12.03 (11.40–12.69) | 13,340.48 | 3.55 (3.47) | 11.83 (11.20) |
| Nervous system disorders | Somnolence | 1340 | 5.34 (5.06–5.64) | 5.27 (4.99–5.55) | 4608.54 | 2.38 (2.30) | 5.23 (4.96) |
| Psychiatric disorders | Drug dependence | 1133 | 4.87 (4.59–5.17) | 4.81 (4.54–5.10) | 3409.00 | 2.25 (2.17) | 4.79 (4.51) |
| Injury, poisoning and procedural complications | Overdose | 1089 | 3.93 (3.70–4.17) | 3.89 (3.66–4.12) | 2327.56 | 1.95 (1.86) | 3.87 (3.64) |
| Psychiatric disorders | Anxiety | 1071 | 2.90 (2.73–3.08) | 2.87 (2.71–3.05) | 1309.60 | 1.52 (1.43) | 2.87 (2.70) |
| Psychiatric disorders | Sopor | 1065 | 64.03 (60.10–68.22) | 63.16 (59.33–67.24) | 59,311.78 | 5.77 (5.68) | 57.57 (54.04) |
| Psychiatric disorders | Suicide attempt | 1031 | 13.75 (12.92–14.63) | 13.58 (12.77–14.43) | 11,772.48 | 3.72 (3.63) | 13.31 (12.51) |
| Injury, poisoning and procedural complications | Intentional overdose | 955 | 12.11 (11.35–12.91) | 11.97 (11.23–12.76) | 9434.09 | 3.54 (3.45) | 11.77 (11.03) |
| Nervous system disorders | Coma | 922 | 15.47 (14.48–16.52) | 15.29 (14.33–16.32) | 12,039.16 | 3.88 (3.78) | 14.96 (14.01) |
| Psychiatric disorders | Insomnia | 824 | 2.40 (2.24–2.57) | 2.38 (2.23–2.55) | 661.74 | 1.25 (1.15) | 2.38 (2.22) |
| Injury, poisoning and procedural complications | Intentional product misuse | 769 | 5.38 (5.01–5.78) | 5.34 (4.97–5.73) | 2691.51 | 2.40 (2.29) | 5.30 (4.93) |
| General disorders and administration site conditions | Feeling abnormal | 750 | 2.34 (2.18–2.52) | 2.33 (2.17–2.50) | 569.39 | 1.21 (1.11) | 2.32 (2.16) |
| General disorders and administration site conditions | Withdrawal syndrome | 625 | 12.82 (11.84–13.88) | 12.73 (11.76–13.77) | 6625.72 | 3.62 (3.50) | 12.50 (11.54) |
| Psychiatric disorders | Confusional state | 601 | 2.90 (2.68–3.14) | 2.88 (2.66–3.12) | 738.67 | 1.52 (1.40) | 2.88 (2.65) |
| Cardiac disorders | Cardiac arrest | 587 | 5.43 (5.01–5.90) | 5.40 (4.98–5.86) | 2090.41 | 2.41 (2.29) | 5.36 (4.94) |
| Cardiac disorders | Cardio-respiratory arrest | 530 | 9.43 (8.66–10.28) | 9.38 (8.61–10.21) | 3910.91 | 3.19 (3.06) | 9.25 (8.49) |
| Nervous system disorders | Loss of consciousness | 523 | 3.17 (2.91–3.46) | 3.16 (2.90–3.44) | 769.72 | 1.65 (1.52) | 3.15 (2.89) |
| Respiratory, thoracic and mediastinal disorders | Respiratory arrest | 513 | 13.45 (12.32–14.68) | 13.37 (12.25–14.58) | 5751.50 | 3.68 (3.55) | 13.11 (12.01) |
| Nervous system disorders | Tremor | 491 | 2.27 (2.07–2.48) | 2.26 (2.07–2.47) | 343.81 | 1.17 (1.04) | 2.25 (2.06) |
| General disorders and administration site conditions | Drug interaction | 487 | 2.41 (2.20–2.64) | 2.40 (2.20–2.62) | 397.87 | 1.26 (1.13) | 2.40 (2.19) |
| Psychiatric disorders | Intentional self-injury | 479 | 15.73 (14.36–17.23) | 15.64 (14.29–17.12) | 6409.29 | 3.89 (3.76) | 15.29 (13.96) |
| Injury, poisoning and procedural complications | Poisoning deliberate | 463 | 54.86 (49.88–60.33) | 54.53 (49.61–59.95) | 22,422.49 | 5.51 (5.37) | 50.33 (45.76) |
| General disorders and administration site conditions | Drug withdrawal syndrome | 425 | 3.26 (2.97–3.59) | 3.25 (2.96–3.57) | 660.02 | 1.69 (1.55) | 3.24 (2.94) |
| Psychiatric disorders | Suicidal ideation | 380 | 3.24 (2.93–3.58) | 3.23 (2.92–3.57) | 581.80 | 1.68 (1.53) | 3.22 (2.91) |
| Psychiatric disorders | Panic attack | 379 | 8.20 (7.41–9.08) | 8.16 (7.38–9.03) | 2354.32 | 2.99 (2.84) | 8.07 (7.29) |
| Nervous system disorders | Depressed level of consciousness | 378 | 7.48 (6.76–8.28) | 7.45 (6.73–8.24) | 2087.76 | 2.86 (2.71) | 7.38 (6.66) |
| Psychiatric disorders | Agitation | 377 | 3.84 (3.47–4.25) | 3.83 (3.46–4.23) | 783.27 | 1.92 (1.77) | 3.81 (3.44) |
| Cardiac disorders | Tachycardia | 269 | 2.39 (2.12–2.69) | 2.38 (2.11–2.69) | 215.53 | 1.24 (1.07) | 2.38 (2.11) |