Table 2.
Acute toxicities during the total neoadjuvant therapy.
| Toxicitiesa | NCRT N = 46 (%) |
CNCT N = 41 (%) |
||
|---|---|---|---|---|
| Grade 1–2 | ≥ Grade 3 | Grade 1–2 | ≥ Grade 3 | |
| Hematological | ||||
| Leukopenia | 36 (78.3) | 0 | 30 (73.2) | 4 (9.7) |
| Thrombocytopenia | 4 (8.7) | 1 (2.2) | 9 (21.9) | 5 (12.2) |
| Anemia | 7 (15.2) | 0 | 12 (29.3) | 0 |
| Non-hematological | ||||
| Fatigue | 24 (52.1) | 0 | 24 (58.5) | 1 (2.4) |
| Bleeding | 0 | 1 (2.2) | 0 | 0 |
| Diarrhea | 1 (2.2) | 0 | 3 (7.3) | 0 |
| Anorexia | 37 (80.4) | 1 (2.2) | 26 (63.4) | 1 (2.4) |
| Nausea | 32 (69.5) | 1 (2.2) | 24 (58.5) | 3 (7.3) |
| Vomiting | 20 (43.5) | 0 | 10 (24.4) | 0 |
| Pain | 11 (23.9) | 1 (2.2) | 4 (9.7) | 0 |
| Dermatitis | 4 (8.7) | 0 | 0 | 0 |
| Weight loss | 2 (4.3) | 0 | 2 (4.9) | 0 |
| Hand-foot syndrome | 1 (2.2) | 0 | 4 (9.8) | 0 |
aCTCAE version 3.0, NCRT, neoadjuvant chemoradiotherapy; CNCT, concurrent neoadjuvant chemotherapy.