Fig. 3. Hormone receptor (ER, PR, Her2) and tumor cell proliferation (Ki-67) changes during metastasis.

Data variables from clinical biopsies were combined with post-mortem evaluations to create a visual depiction of changes in tumor marker expressions overtime, where 0 months represents a patient’s first biopsy. When multiple values are present at a single timepoint, the black trend line corresponds to the average of all values. Due to discrepancies in standard-of-care practices, not all historical data variables were available for all patients.