Table 1.

Patient characteristics and disease history

Disease characteristics at diagnosis							Metastatic disease history and unexpected post-mortem findings
Patient	Age (years)	Race	Type	Subtype	Stage	TNM	Primary to metastatic Dx (months)	Metastatic Dx to death (months)	Primary Dx to death (months)	Clinically Diagnosed Metastatic Organ Involvement	Undiagnosed Findings Post-mortem	Micrometastases Identified by IF
1	46	Asian	IDC	Low HR / TNBC	IIA	T1N1a	19	10	29	L breast, Skin, Shoulder musculature, Chest wall, L Lung	N/A	N/A
2	31	Caucasian	IDC	HR+	IIA	T2N0	16	31	47	R breast, Lungs, Liver, Adrenals, Bone, Brain	Anterior Chest Mass, Spleen, Ovaries, Dura	Pancreas
3	32	Caucasian	IDC	HR+	IIIB	T3N1a	54	86	140	L breast, Anterior chest mass, Thyroid, Lungs, Liver, Bone	Pancreas, Adrenals	N/A
4	47	Middle Eastern	IDC	HR+	IIB	T2 N1a	125	163	284	L breast, Chest wall, Liver, Bone, Brain	R Lung, Adrenal	Non-tumor-draining lymph nodes
5	37	Caucasian	IDC	TNBC	III/IV	T4dN1	1	12	13	L breast, Skin, Bone	R Breast	Non-tumor-draining lymph nodes
6	67	Caucasian	IDC	Low HR /TNBC	II	T2N0	30	30	60	L Breast, Anterior Chest Mass, Chest wall, Lungs, Abdominal mass, Bone, Brain	Liver	N/A
7	58	Caucasian	Lobular	HR+	IV	N/A*	De novo metastatic	35	35	R breast, GI, Bone, Brain, Lung	N/A	N/A
8	69	Caucasian	IDC	HR+	I	T3mN0	27	7	34	L + R breast, Skin, R Lung, Liver, Brain	L Lung, R Adrenal, Kidneys	N/A
	69		IDC	TNBC	IIa	cT2cN0
9	53	Asian	IDC	Low HR /TNBC	IIIC	cT2-3N3	7	6	13	R breast, Liver, Bone, Skin	L Breast, R Chest Wall, L Lung, Adrenals**	Spleen, Bone, Non-tumor-draining lymph nodes

*De novo metastatic with occult primary ** Not diagnosed but identified on imaging retrospectively; IDC invasive ductal carcinoma, TNBC triple-negative breast cancer, HR hormone receptor, TNM tumor, node, metastasis, L left, R right, GI gastro-intestinal.