. 2024 Mar 29;14:7480. doi: 10.1038/s41598-024-57858-6

Table 2.

Incident diagnosis of cardiovascular outcomes in the HEXA study population.

Outcomes	Number of events		Crude incidence rate per 1000 person-years		Unadjusted HR (95% CI)	Model 1 HR (95% CI)	Model 2 HR (95% CI)	Model 3 HR (95% CI)
Outcomes	Control	History of PE	Control	History of PE	Unadjusted HR (95% CI)	Model 1 HR (95% CI)	Model 2 HR (95% CI)	Model 3 HR (95% CI)
IHD	710/65,245 (1.09%)	57/3413 (1.67%)	0.530	0.822***	1.58***	1.59***	1.59***	1.56**
IHD	710/65,245 (1.09%)	57/3413 (1.67%)	0.530	0.822***	(1.21–2.07)	(1.21–2.08)	(1.21–2.08)	(1.19–2.04)
Stroke	374/65,245 (0.57%)	30/3413 (0.88%)	0.279	0.434***	1.57*	1.57*	1.54*	1.48*
Stroke	374/65,245 (0.57%)	30/3413 (0.88%)	0.279	0.434***	(1.08–2.28)	(1.08–2.28)	(1.06–2.24)	(1.02–2.16)

Data are presented as proportion (%).

CI, confidence interval; CVD, cardiovascular diseases; HR, hazard ratio; IHD, ischemic heart diseases; PE, preeclampsia.

Significant codes: ‘***’ < 0.001; ‘**’ < 0.01; ‘*’ < 0.05.

Model 1, adjusted for age at delivery and parity using Cox proportional hazards regression analysis.

Model 2, adjusted for age at delivery, parity, and prevalent diseases (hypertension, diabetes, or dyslipidemia) using Cox proportional hazards regression analysis.

Model 3, adjusted for age at delivery, parity, prevalent diseases (hypertension, diabetes, or dyslipidemia), and family history (ischemic heart disease or stroke) using Cox proportional hazards regression analysis.