Table 3.
Adjusted effect of clinical factors contributing to the annual FEV1 change in COPD patients.
| Annual FEV1 change, mL/year |
P-value | ||
|---|---|---|---|
| Beta-coefficient | Standard error | ||
| Age | −16.73 | 2.29 | <0.001 |
| Sex, female | −458.15 | 70.29 | <0.001 |
| Current smoker | −23.637 | 72.47 | 0.744 |
| CCI ≥3 | 124.1 | 39.08 | 0.001 |
| CAT score | −6.45 | 2.10 | 0.002 |
| Moderate-to-severe exacerbation history within previous 1 year | −238.95 | 41.50 | <0.001 |
| Baseline FVC, % of predicted value | 17.15 | 1.12 | <0.001 |
| Structural abnormality on chest CT | −70.59 | 34.08 | 0.039 |
The results of multivariable linear mixed effect model were summarized as slope estimate %/year (standard error).
BMI and baseline FEV1 were not included for multivariable analysis because of multicollinearity with structural abnormality.
CAT, COPD assessment test; CCI, Charlson comorbidity index; COPD, chronic obstructive pulmonary disease; CT, computed tomography; FVC, forced vital capacity.