Table 2.

Methods or substances related to ANGPTLs for the treatment of NAFLD and its related diseases.

Therapy	Method/Substance	Action pathway	effect	Reference(s)
Lifestyle change	Exercise	Increased ANGPTL4 levels and decreased ANGPTL8 levels	Prevent and slow down the progression of NAFLD lesions	[[129], [130], [131]]
	Dietary restriction	Increased ANGPTL4 levels and decreased ANGPTL8 levels	Promotes fat burning, reduces fat storage, prevents and treats NAFLD	[[132], [133], [134], [135]]
Treatment related to NAFLD	Berberine	Regulating the ANGPTL2 pathway	Reducing the inflammatory response of the liver	[53]
	Dihydroartemisinin (DHA)	Inhibition of ANGPTL2 expression	Inhibitory effect on HCC	[136]
	Monoclonal antibodies and antisense oligonucleotides	Direct targeting of ANGPTLs	Improve lipid metabolism and play a role in NAFLD prevention and treatment	[120,[137], [138], [139],144]
	Tangeretin	Adjusting the LXRα-ANGPTL3-LPL Pathway	Prevention and treatment of dyslipidemia and related diseases	[140]
	Statin	Reduces ANGPTL3 concentration by decreasing LXR activation	More effective lipid-lowering effect	[141]
	Paeoniflorin	Regulating the GALNT2-ANGPTL3-LPL Pathway	Improvement of dyslipidemia	[142]
	Undaria pinnatifida (UP)	Regulating the ANGPTL3-LPL Pathway	alleviate hyperlipidemia	[143]
	Royal jelly fatty acids	Reduction of HNF4α protein to inhibit ANGPTL8 expression	Improvement of abnormal lipid metabolism	[145]
	Metformin	Inhibition of ANGPTL8 expression	Prevention of liver fibrosis	[124]
	gene editing and RNA interference	Specific targeting of ANGPTLs	Exercise the corresponding biological effects to improve NAFLD	[146]