Table 2.

Optimism-corrected discriminative ability (C-statistic) of serum log (NfL) measured at different time points adjusted for individual components of the mEGOS.

Outcome: Inability to walk unaided at 4 weeks
Time	Reference model		Model with log (NfL)		Delta C-statistic	Delta R2%
	C-statistic	R2%	C-statistic	R2%
Entry	0.822 (0.747–0.886)	40.1 (24.2–54.7)	0.853 (0.780–0.903)	46.0 (30.7–58.8)	0.031 (0.001–0.081)	5.9 (−0.2 to 15.9)
Week 1	0.861 (0.811–0.897)	48.7 (36.5–59.7)	0.864 (0.810–0.899)	50.8 (38.3–61.2)	0.004 (−0.006 to 0.020)	2.0 (−0.2 to 6.1)
Week 2	0.880 (0.831–0.926)	52.4 (40.5–66.8)	0.891 (0.842–0.929)	56.3 (44.2–68.0)	0.011 (−0.006 to 0.035)	3.9 (−0.5 to 10.5)
Week 4	0.845 (0.791–0.893)	46.1 (32.7–57.9)	0.858 (0.808–0.903)	49.6 (37.8–61.1)	0.012 (−0.005 to 0.039)	3.5 (−0.6 to 9.5)
Outcome: Inability to walk unaided at 26 weeks
Time	Reference model		Model with log(NfL)		Delta C-statistic	Delta R2%
	C-statistic	R2%	C-statistic	R2%
Entry	0.727 (0.613–0.837)	15.2 (0–35.1)	0.836 (0.721–0.915)	30.2 (8.6–51.3)	0.109 (0.008–0.221)	14.9 (0.6–33.1)
Week 1	0.813 (0.736–0.879)	29.1 (13.8–43.8)	0.820 (0.740–0.887)	33.5 (16.5–47.3)	0.007 (−0.020 to 0.048)	4.3 (−1.0 to 14.2)
Week 2	0.819 (0.736–0.894)	32.0 (16.6–48.7)	0.832 (0.743–0.909)	35.7 (17.9–53.1)	0.012 (−0.015 to 0.053)	3.7 (−1.7 to 12.9)
Week 4	0.792 (0.710–0.865)	28.3 (12.9–46.1)	0.851 (0.770–0.928)	40.9 (23.6–58.3)	0.060 (0.027–0.101)	12.6 (7.4–21.8)

Data in parentheses represent the 95% confidence intervals. Time represents NfL measurement at entry or after initiation of the first course of IVIg. The reference model includes: age, preceding diarrhoea, and MRC sum score at week 1. Delta C-statistic and Delta R² represent the differences between the model with log (NfL) and the reference model. Abbreviation: NfL, Neurofilament light chain.