Table 3.
Clinical pathology, urinalysis and histopathology of the rat after repeated administration of SUL-138 and after recovery.
|
Sex |
Male |
Female |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group | Main | Recovery | Main | Recovery | ||||||||
| Dose (mg/kg) | 0 | 27 | 136 | 682 | 0 | 682 | 0 | 27 | 136 | 682 | 0 | 682 |
| Mean terminal body weight (g) | 345.13 ± 17.30 | 344.07 ± 21.31 | 348.24 ± 9.48 | 339.06 ± 18.53 | 367.90 ± 18.86 | 367.96 ± 19.52 | 223.51 ± 10.10 | 226.47 ± 11.92 | 218.65 ± 8.75 | 224.24 ± 13.64 | 238.04 ± 13.99 | 227.62 ± 5.58 |
| Kidneys | ||||||||||||
| Urinary volume (mL) | 4.10 ± 1.97 | 5.40 ± 1.37 | 4.30 ± 1.16 | 5.50 ± 2.46 | 3.40 ± 2.07 | 3.60 ± 1.39 | 2.45 ± 1.66 | 2.40 ± 1.04 | 2.45 ± 1.04 | 3.83 ± 1.85 | 1.80 ± 1.10 | 1.50 ± 0 |
| Kidney weight (g) | 2.522 ± 0.18 | 2.446 ± 0.15 | 2.515 ± 0.13 | 2.564 ± 0.19 | 2.469 ± 0.15 | 2.765* ± 0.21 | 1.506 ± 0.14 | 1.522 ± 0.09 | 1.456 ± 0.08 | 1.541 ± 0.11 | 1.465 ± 0.18 | 1.525 ± 0.09 |
| Kidney/body weight (%) | 0.73 ± 0.04 | 0.71 ± 0.03 | 0.72 ± 0.03 | 0.76 ± 0.05 | 0.67 ± 0.04 | 0.75* ± 0.07 | 0.67 ± 0.04 | 0.67 ± 0.04 | 0.67 ± 0.03 | 0.69 ± 0.05 | 0.61 ± 0.05 | 0.67 ± 0.04 |
| Tubular basophilia (n) | 10/10 | 8/10 | 7/10 | 9/9* | 3/5 | 5/5 | 3/10 | 3/10 | 4/10 | 8/9* | 2/5 | 4/5 |
| Tubular dilation (n) | 5/10 | 5/10 | 5/10 | 5/9* | 3/5 | 4/5 | 0/10 | 2/10 | 3/10 | 6/9* | 0/5 | 2/5 |
| Casts (n) | 0/10 | 0/10 | 4/10 | 6/9* | 0/5 | 0/5 | 0/10 | 1/10 | 1/10 | 3/9 | 0/5 | 0/5 |
| Hyaline droplets (n) | 0/10 | 0/10 | 2/10 | 6/9* | 0/5 | 0/5 | 0/10 | 0/10 | 0/10 | 0/9 | 0/5 | 0/5 |
| Liver | ||||||||||||
| Plasma cholesterol (mmol/L) | 1.85 ± 0.20 | 1.92 ± 0.16 | 2.22**± 0.08 | 2.77***± 0.37 | 1.61 ± 0.18 | 1.70 ± 0.24 | 2.46 ± 0.34 | 2.41 ± 0.32 | 2.58 ± 0.46 | 3.59***± 0.57 | 2.21 ± 0.57 | 2.30 ± 0.58 |
| Liver weight (g) | 10.173 ± 0.82 | 10.285 ± 0.76 | 11.196* ± 0.29 | 13.217*** ± 1.06 | 9.741 ± 0.54 | 11.746*± 0.94 | 6.357 ± 0.66 | 6.390 ± 0.67 | 6.402 ± 0.40 | 7.820*** ± 1.09 | 6.138 ± 0.88 | 6.290 ± 0.45 |
| Liver/body weight (%) | 2.95 ± 0.17 | 2.99 ± 0.10 | 3.22**± 0.10 | 3.89*** ± 0.24 | 2.65 ± 0.16 | 3.21* ± 0.33 | 2.84 ± 0.22 | 2.82 ± 0.20 | 2.93 ± 0.16 | 3.48*** ± 0.39 | 2.57 ± 0.24 | 2.77 ± 0.24 |
| Hepatocellular vacuolation (n) | 0/10 | 0/10 | 0/10 | 6/9* | 0/5 | 1/5 | 0/10 | 0/10 | 0/10 | 2/9 | 0/5 | 0/5 |
| Hepatocyte hypertrophy (n) | 0/10 | 0/10 | 0/10 | 2/9 | 0/5 | 0/5 | 0/10 | 0/10 | 0/10 | 0/9 | 0/5 | 0/5 |
(* p-value < 0.05 compared to vehicle; ** p-value < 0.05 compared to vehicle and 27 mg/kg; *** p-value < 0.05 compared to vehicle, 27 and 136 mg/kg)