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Receptor function of rat/human CXCR4 chimeras (6) for fusion mediated by FIV. CCC cells were transfected with a panel of rat/human CXCR4 chimeras (a). Thick lines denote regions derived from human CXCR4; thin lines denote regions derived from rat CXCR4. The transfected cells were then assayed for the ability to support fusion with FIVPET- or FIVGL8-infected CrFK cells as described above (b). Results represent the mean (n = 6) number of syncytia per field ± SE.
