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. 2024 Mar 11;27(4):109489. doi: 10.1016/j.isci.2024.109489

Figure 2.

Figure 2

Bacopa monnieri extract alters focal adhesions in fibroblasts

(A) Cellular component analysis from RNA sequencing of fibroblasts treated with Bacopa monnieri extract (left panel). Heatmap of genes associated with focal adhesions (right panel).

(B) qPCR analysis of ARHGAP22 and NEDD9 gene expression.

(C) Vinculin staining (red) in human dermal fibroblast treated with Bacopa monnieri extract or vehicle control, DAPI (blue) marks nuclei (left panel) and quantification of focal adhesion area (right panel). Scale bar 20 μm.

(D and E) Analysis of focal adhesions roundness (D) and number per cell (E). p values were calculated using unpaired Student’s t test. ∗p ≤ 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, vehicle control n = 138 cells, Bacopa monnieri extract n = 144 cells.