REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-integrin β1 antibody (12G10)	Abcam	Cat. #ab30394; RRID:AB_775726
phospho-FAK (Y397)	Thermo Fisher	Cat. #44624g; RRID: AB_2533701
Goat anti Rat Alexa Fluor 488	Invitrogen	Cat.# A11006; RRID: AB_2534074
Goat anti Rat Alexa Fluor 568	Invitrogen	Cat. # A11077; RRID: AB_2534121
Anti-Vinculin	Sigma Aldrich	Cat. #V9264
Chemicals, peptides, and recombinant proteins
Methanol	SPECTROCHEM PVT LTD	71301
RGD peptide	Santacruz Biotechnology Inc (Bibootech)	Cat.SC-201176
FAK inhibitor- PF-573228	Sigma Aldrich	PZ0117
DMEM media	VASA SCIENTIFIC (HIMEDIA)	AT066-10X1L
Cell Proliferation Reagent WST-1 (2X8mL)	Roche	5015944001
PrimeScript cDNA synthesis kit	Takara	Cat.#2680A
Deposited data
RNA sequencing raw data	NCBI data	PRJNA939001
Experimental models: Cell lines
Human adult dermal fibroblasts	Lonza	Cat. Lonza CC-2511
Oligonucleotides
PTGS2 forward primer TCCAATGACTCCCAGTCTGAGGA,	This paper	NA
PTGS2 reverse primer TCAAAGGTCAGCCTGTTTAC	This Paper	NA
KIT forward primer TGTGTTGTCACCCAAGAGATT	This Paper	NA
KIT reverse primer CAATGAAGTGCCCCTGAAG	This Paper	NA
ARHGAP22 forward primer TACAGGGGCTGGTCACTGAG	This Paper	NA
ARHGAP22 reverse primer GTTCCGCAGCTTTATTTCCA	This Paper	NA
NEDD9 forward primer GCCTCTAGAAGCAAGTCCGC	This Paper	NA
NEDD9 reverse primer GGGAGGTGACAGCTAGTCCT.	This Paper	NA
Software and algorithms
ImageJ software (Fiji)	Schneider et, al.32	https://imagej.nih.gov/ij/
Prism version 7.0	GraphPad	https://www.graphpad.com/