Fig. 1. Inferring DNA methylation from high-coverage whole-genome bisulfite sequencing.

a The correlation between mean DNA methylation and fragment lengths in cfDNA and gDNA WGBS in healthy individuals. b Diagram of the features utilized for the inference of DNA methylation level. Unmethy: unmethylated CpG. Methy: methylated CpG. c Receiver operating characteristic curve (ROC) for the model performance at deep WGBS in fragments with different numbers of CpGs. AUC: Area under the ROC Curve. Red line represents the ROC for fragments with equal or more than 5 CpGs. Yellow line represents the ROC for fragments with equal or more than 3 CpGs. Blue line represents the ROC for fragments with equal or more than 1 CpG. Source data are provided as a Source Data file.