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. 2024 Mar 30;14:170. doi: 10.1038/s41398-024-02877-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Chronic stress disrupts dorsal and ventral regional distribution of proliferating (Ki67+) cells in DG subregions and AM630 treatment in combination with PE restores regional disturbances. b Quantitative analysis of the dorsal (b1) and ventral (b2) SGZ/GCL subregional preference for the location of proliferating cells. c Quantitative analysis of the dorsal (c1) and ventral (c2) supra/infrapyramidal subregional preference for the location of proliferating cells. d Chronic stress disrupts dorsal/ventral (d1) and supra/infrapyramidal (d2) regional distribution of proliferating neuroblasts (Ki67+DCX+), that is rescued by AM630 treatment in combination with PE. e Chronic stress alters the balance between progenitor and immature DCX+ cells, which is restored by AM630 treatment in combination with PE (e1); quantitative analysis of the dorsal/ventral (e2) and supra/infrapyramidal (e3) subregional preference for the location of DCX+ cells. f Chronic stress disrupts dorsal and ventral regional distribution of newly born neurons (BrdU+NeuN+) in different DG subregions; AM630 treatment in combination with PE restores these regional disturbances. g Quantitative analysis of the dorsal (g1) and ventral (g2) SGZ/GCL subregional preference for the location of newly born neurons. h Quantitative analysis of the dorsal (h1) and ventral (h2) supra/infrapyramidal subregional preference for the location of newly born neurons. Data presented as mean ± SEM (except for donut plots where only mean is presented) [Student’s t test: ****p < 0.0001. ***p < 0.001, **p < 0.01, *p < 0.05; further statistical details in Table S4]. Supra suprapyramidal blade; Infra infrapyramidal blade, SGZ subgranular zone, GCL granule cell layer, uCMS unpredictable chronic mild stress, AM630 CB2R inverse agonist, PE physical exercise.