1 Number of participants with at least one exacerbation (ICS and OCS users) |
10 |
3261 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.55 [0.46, 0.65] |
1.1 Moderate to severe |
7 |
2889 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.50 [0.42, 0.60] |
1.2 Severe (ICS) |
2 |
277 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.00 [0.50, 1.99] |
1.3 Severe (ICS and OCS) |
1 |
95 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.65 [0.66, 4.13] |
2 Exacerbations requiring oral steroids |
3 |
|
Rate Ratio (Fixed, 95% CI) |
Subtotals only |
2.1 Moderate to severe asthma (ICS + mixed treatments) |
2 |
|
Rate Ratio (Fixed, 95% CI) |
0.52 [0.37, 0.73] |
2.2 Severe asthma (ICS + LABA) |
1 |
|
Rate Ratio (Fixed, 95% CI) |
0.66 [0.45, 0.97] |
2.3 Severe asthma (ICS + LABA + other treatment) |
1 |
|
Rate Ratio (Fixed, 95% CI) |
0.72 [0.53, 0.98] |
2.4 Severe asthma (ICS and OCS) |
1 |
|
Rate Ratio (Fixed, 95% CI) |
0.95 [0.63, 1.43] |
3 Hospitalisations |
4 |
1824 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.16 [0.06, 0.42] |
3.1 Moderate to severe asthma |
4 |
1824 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.16 [0.06, 0.42] |
3.2 Severe asthma |
0 |
0 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
4 Mortality |
9 |
4245 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.19 [0.02, 1.67] |
4.1 Moderate to severe asthma |
7 |
3124 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.32 [0.01, 7.85] |
4.2 Severe asthma |
2 |
1121 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.14 [0.01, 2.73] |
5 Peak expiratory flow rate (am) |
4 |
1651 |
Mean Difference (IV, Fixed, 95% CI) |
3.56 [‐5.05, 12.18] |
5.1 Moderate to severe asthma |
3 |
1405 |
Mean Difference (IV, Fixed, 95% CI) |
4.93 [‐4.11, 13.97] |
5.2 Severe asthma |
1 |
246 |
Mean Difference (IV, Fixed, 95% CI) |
‐9.90 [‐38.27, 18.47] |
6 Change in am PEF |
2 |
|
Mean Difference (Fixed, 95% CI) |
Totals not selected |
6.1 Moderate to severe asthma |
1 |
|
Mean Difference (Fixed, 95% CI) |
0.0 [0.0, 0.0] |
6.2 Severe asthma |
1 |
|
Mean Difference (Fixed, 95% CI) |
0.0 [0.0, 0.0] |
7 FEV1 (mL) |
2 |
1071 |
Mean Difference (IV, Fixed, 95% CI) |
68.31 [‐23.45, 160.07] |
7.1 Moderate to severe |
2 |
1071 |
Mean Difference (IV, Fixed, 95% CI) |
68.31 [‐23.45, 160.07] |
7.2 Severe |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
8 Change in FEV1 (mL) |
5 |
1463 |
Mean Difference (Fixed, 95% CI) |
56.39 [16.82, 95.96] |
8.1 Moderate to severe asthma |
2 |
732 |
Mean Difference (Fixed, 95% CI) |
67.29 [23.75, 110.83] |
8.2 Severe asthma |
3 |
731 |
Mean Difference (Fixed, 95% CI) |
4.68 [‐90.16, 99.52] |
9 Change in FEV1 predicted |
4 |
1498 |
Mean Difference (Fixed, 95% CI) |
2.15 [1.01, 3.30] |
9.1 Moderate to severe asthma |
3 |
1079 |
Mean Difference (Fixed, 95% CI) |
2.01 [0.76, 3.27] |
9.2 Severe asthma |
1 |
419 |
Mean Difference (Fixed, 95% CI) |
2.8 [0.10, 5.50] |
10 Symptom scores |
10 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
10.1 Moderate to severe asthma |
6 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
10.2 Severe asthma |
4 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
11 Mean change in Wasserfallen asthma score |
1 |
|
Symptoms (Fixed, 95% CI) |
Totals not selected |
11.1 Moderate to severe asthma |
1 |
|
Symptoms (Fixed, 95% CI) |
0.0 [0.0, 0.0] |
12 Quality of life—change from baseline in AQLQ scores |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
12.1 Moderate to severe asthma |
0 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
12.2 Severe asthma |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
13 Global evaluation rated good to excellent |
4 |
1136 |
Odds Ratio (M‐H, Fixed, 95% CI) |
2.12 [1.67, 2.68] |
13.1 Moderate to severe asthma |
1 |
405 |
Odds Ratio (M‐H, Fixed, 95% CI) |
3.32 [2.19, 5.05] |
13.2 Severe asthma |
3 |
731 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.69 [1.26, 2.26] |
14 Rescue medication |
9 |
|
Mean Difference (Fixed, 95% CI) |
Subtotals only |
14.1 Moderate to severe asthma |
4 |
|
Mean Difference (Fixed, 95% CI) |
‐0.58 [‐0.84, ‐0.31] |
14.2 Severe asthma (ICS) |
4 |
|
Mean Difference (Fixed, 95% CI) |
‐0.30 [‐0.49, ‐0.10] |
14.3 Severe asthma (ICS and OCS) |
1 |
|
Mean Difference (Fixed, 95% CI) |
‐0.4 [‐4.81, 4.01] |
15 Adverse event—any |
14 |
5167 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.92 [0.81, 1.06] |
15.1 Moderate to severe asthma |
8 |
3246 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.91 [0.76, 1.09] |
15.2 Severe asthma |
6 |
1921 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.94 [0.76, 1.16] |
16 Adverse event—serious |
15 |
5713 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.72 [0.57, 0.91] |
16.1 Moderate to severe asthma |
9 |
3792 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.68 [0.48, 0.95] |
16.2 Severe asthma |
6 |
1921 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.77 [0.56, 1.05] |
17 Injection site reactions |
9 |
3577 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.72 [1.33, 2.24] |
17.1 Moderate to severe asthma |
6 |
2001 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.79 [1.31, 2.43] |
17.2 Severe asthma |
3 |
1576 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.57 [0.96, 2.57] |