1 Number of participants with exacerbation |
5 |
1726 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.49 [0.39, 0.62] |
1.1 Moderate to severe asthma |
3 |
1388 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.46 [0.36, 0.59] |
1.2 Severe asthma |
1 |
246 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.59 [0.30, 1.16] |
1.3 Severe (ICS and OCS users) |
1 |
92 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.88 [0.38, 2.01] |
2 Exacerbations requiring hospitalisation |
3 |
1405 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.11 [0.03, 0.48] |
2.1 Moderate asthma |
3 |
1405 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.11 [0.03, 0.48] |
2.2 Severe asthma |
0 |
0 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
3 Number of participants achieving complete inhaled steroid withdrawal |
4 |
1634 |
Odds Ratio (M‐H, Fixed, 95% CI) |
2.50 [2.00, 3.13] |
3.1 Moderate to severe |
3 |
1388 |
Odds Ratio (M‐H, Fixed, 95% CI) |
2.67 [2.10, 3.39] |
3.2 Severe |
1 |
246 |
Odds Ratio (M‐H, Fixed, 95% CI) |
1.55 [0.80, 2.98] |
4 Mean change in steroid consumption (BDP equivalent) |
3 |
1188 |
Mean Difference (IV, Fixed, 95% CI) |
‐118.76 [‐154.38, ‐83.14] |
4.1 Moderate to severe asthma |
2 |
942 |
Mean Difference (IV, Fixed, 95% CI) |
‐114.08 [‐150.03, ‐78.13] |
4.2 Severe asthma |
1 |
246 |
Mean Difference (IV, Fixed, 95% CI) |
‐372.0 [‐636.43, ‐107.57] |
5 > 50% reduction in inhaled steroid usage |
4 |
1634 |
Odds Ratio (M‐H, Fixed, 95% CI) |
2.50 [2.02, 3.10] |
5.1 Moderate to severe asthma |
3 |
1388 |
Odds Ratio (M‐H, Fixed, 95% CI) |
2.44 [1.93, 3.08] |
5.2 Severe asthma |
1 |
246 |
Odds Ratio (M‐H, Fixed, 95% CI) |
2.84 [1.66, 4.86] |
6 Mean steroid dose at end of reduction phase |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
6.1 Moderate to severe asthma |
0 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
6.2 Severe asthma |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
7 Quality of life—change from baseline |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
Totals not selected |
7.1 Moderate to severe asthma |
0 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
7.2 Severe asthma |
1 |
|
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
8 Numbers of participants achieving clinically relevant improvement in quality of life (> 0.5) |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
Totals not selected |
8.1 Severe asthma |
1 |
|
Odds Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
9 Global evaluation rated good to excellent |
2 |
842 |
Odds Ratio (M‐H, Fixed, 95% CI) |
2.72 [2.04, 3.62] |
9.1 Moderate to severe asthma |
2 |
842 |
Odds Ratio (M‐H, Fixed, 95% CI) |
2.72 [2.04, 3.62] |
9.2 Severe asthma |
0 |
0 |
Odds Ratio (M‐H, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
10 Rescue medication (puffs per day) |
4 |
1373 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.74 [‐1.05, ‐0.43] |
10.1 Moderate to severe asthma |
2 |
1071 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.73 [‐1.06, ‐0.40] |
10.2 Severe asthma (ICS) |
1 |
220 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.7 [‐1.65, 0.25] |
10.3 Severe asthma (ICS and OCS) |
1 |
82 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.80 [‐7.40, 1.80] |