1. Adverse effects for NSAIDs versus NSAIDs.

Study	Comparison		GI		CNS		Injection site		Other
	NSAID (1)	NSAID (2)	NSAID (1)	NSAID (2)	NSAID (1)	NSAID (2)	NSAID (1)	NSAID (2)	NSAID (1)	NSAID (2)
Sanchez‐Carpena 2003	Dexketoprofen	Dipyrone	2/225	7/108	6	4	10	7	3	2
Sanchez‐Carpena 2007	Dexketoprofen	Dipyrone	39/205	22/103	4	3	19	0	6	0
Sanahuja 1990	Diclofenac	Baralgan	0/29	0/28	0	0	0	0	1	1
Indudhara 1990	Diclofenac	Baralgan	2/33	6/30	0	0	0	0	0	0
Miralles 1987	Diclofenac	Dipyrone	Adverse effects not reported
Muriel‐Villoria 1995	Diclofenac	Dipyrone	24/55	18/239	104	134	1	4	‐‐	‐‐
Muriel 1993	Diclofenac	Dipyrone	6/41	11/88	59	85	1	2	‐‐	‐‐
Arnau 1991	Diclofenac	Dipyrone	26/116	45/227	65	157	13	32	11	37
Marthak 1991	Diclofenac	Dipyrone + antispasmodic	5/82	8/85	0	2	1	0	1	1
Fraga 2003	Diclofenac	Etofenamate	4/60	0/59	1	1	0	1	0	0
el‐Sherif 1990	Diclofenac	Indomethacin	3/47	3/44	0	1	0	0	0	1
Laerum 1996	Diclofenac	Indomethacin	3/41	6/42	1	2	1	1	‐‐	‐‐
Walden 1993	Diclofenac	Ketoprofen	Total adverse effects: NSAID 1 (7/45); NSAID 2 (10/41)
Stein 1996	Diclofenac	Ketorolac	0/30	0/27	0	2	0	0	0	0
Cohen 1998	Diclofenac	Ketorolac	0	0	0	0	0	0	0	0
Al Waili 1999	Diclofenac	Piroxicam	0	0	0	0	0	0	0	0
Supervia 1998	Diclofenac	Piroxicam	0	0	1/40	0	0	0	0	0
Mora Durban 1995	Flurbiprofen	Dipyrone + hyoscine	0	0	‐‐	‐‐	33/67	43/68	‐‐	‐‐
al‐Sahlawi 1996	Indomethacin	Lysine acetyl salicylate	Adverse effects not reported
Lehtonen 1983	Indomethacin	Metamizole	12	7	12	3	0	0	0	1
Galassi 1983	Indomethacin	Metamizole	14/18	0/14	5	0	0	0	12	0
Lupi 1986	Indomethacin	Pirprofen	2
Glina 2011	Ketoprofen	Parecoxib	14/164	11/174	6	10	‐‐	‐‐	‐‐	‐‐
Martin Carrasco 1993	Ketorolac	Dipyrone + antispasmodic	1
Boubaker 2010	Piroxicam	Piroxicam + phloroglucinol	9/127	10/126	3	7	4	3	‐‐	‐‐
Kekec 2000	Tenoxicam	Tenoxicam + isosorbide	0	0	0	0	0	0	0	0

CNS ‐ central nervous system; GI ‐ gastrointestinal; NSAID ‐ nonsteroidal anti‐inflammatory drug