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. 2015 Jun 29;2015(6):CD006027. doi: 10.1002/14651858.CD006027.pub2

Chaudhary 1999.

Methods

  • Study design: parallel RCT

  • Study duration: NS

  • Duration of follow‐up: 120 min
Participants

  • Country: India

  • Setting: Multicentre

  • Patients with biliary (84), renal (58), and intestinal colic (48)

  • Number: treatment group 1 (28); treatment group 2 (40); 200 enrolled in total

  • Age range: 16 to 60 years

  • Sex (M/F): 112/88

  • Exclusion criteria: peptic ulcer disease; glaucoma, hypertension; pregnancy; sensitivity to NSAID
Interventions Treatment group 1

  • Diclofenac (oral)

  • Pitofenone (oral)

  • Fenpiverinium (oral)


Treatment group 2

  • Metamizole (oral)

  • Pitofenone (oral)

  • Fenpiverinium (oral)
Outcomes

  • VAS‐100: 0, 30, 60, 120 min

  • Pain intensity pre‐post treatment after 2 h
Notes

  • Source of funding: Panacea Biotec Ltd
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Not reported
Allocation concealment (selection bias) Unclear risk Not reported
Blinding (performance bias and detection bias) 
 Medication used Low risk Double blind, participants and investigators
Incomplete outcome data (attrition bias) 
 All outcomes Low risk No missing outcome data
Selective reporting (reporting bias) Low risk All pre‐specified primary and secondary outcomes are reported
Other bias Unclear risk Industry sponsorship could be a source of bias