Iguchi 2002.

Methods	Study design: parallel RCT Study duration: started January 1999 Duration of follow‐up: 24 h
Participants	Country: Japan Setting: single centre Patients with renal colic Number: treatment group 1 (30); treatment group 2 (30) Mean age ± SD (years): treatment group 1 (43.3 ± 14.8); treatment group 2 (41.3 ± 12.4) Sex (M/F): treatment group 1 (23/7); treatment group 2 (21/9) Exclusion criteria: previous history of renal colic treatment; allergy, lower abdominal pain
Interventions	Treatment group 1 Butylscopolamine: 40 mg (IV) Sulpyrine: 500 mg (IV) 5% glucose: 20 mL (IV) Treatment group 2 1% lidocaine: 10 to 15 mL to trigger point (local)
Outcomes	VAS‐100: 10, 20, 30, 40, 50, 60 min
Notes	Source of funding: NS
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Only described as simple randomisation
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding (performance bias and detection bias) Medication used	High risk	Not blinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing outcome data
Selective reporting (reporting bias)	Low risk	All pre‐specified primary and secondary outcomes are reported
Other bias	Low risk	The study appears to be free of other sources of bias