Lloret 1987.

Methods	Study design: parallel RCT Study duration: NS Duration of follow‐up: 30 min
Participants	Country: Spain Setting: multicentre Number: treatment group 1 (25); treatment group 2 (25); treatment group 3 (23); treatment group 4 (23) Mean age ± SD (years): treatment group 1 (38.6 ± 14.9); treatment group 2 (42.9 ± 19.9); treatment group 3 (43.8 ± 14.5); treatment group 4 (36.9 ± 15.3) Sex (M/F): NS Exclusion criteria: pregnancy; glaucoma; hypertension; cardiac failure; megacolon; hepato cellular
Interventions	Treatment group 1 Dipyrone: 2.5 g Treatment group 2 Dipyrone: 2.5 mg Hyoscine: 20 mg Treatment group 3 Dipyrone: 1 g Treatment group 4 Hyoscine: 20 mg
Outcomes	VAS‐100: 10, 20, 30 min Need for rescue medication
Notes	Source of funding: NS
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomisation list
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding (performance bias and detection bias) Medication used	Low risk	Double blind; patient and observer
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing outcome data
Selective reporting (reporting bias)	Low risk	All pre‐specified primary and secondary outcomes are reported
Other bias	Low risk	The study appears to be free of other sources of bias